To interrelate in vivo wall shear stress, endothelial microfilament bundle formation, and atherosclerosis localization, we used a mild abdominal aortic stenosis in 11 beagles to produce a range of wall shear stresses above and below the constriction. Six of the beagles were fed standard animal chow supplemented with 5% cholesterol and 10% coconut oil. Wall shear stresses, endothelial microfilam...

In this study, we investigated inelastic non-Newtonian fluid flow over heterogeneously slippery surfaces. First, we simulated the flow of aqueous xanthan gum solutions over a bubble mattress, which is a superhydrophobic surface consisting of transversely positioned no-slip walls and no-shear gas bubbles. The results reveal that for shear-thinning fluids wall slip can be increased significantly,...

Increased pulmonary blood flow (PBF) is widely thought to provoke pulmonary vascular obstructive disease (PVO), but the impact of wall shear stress in the lung is actually poorly defined. We examined information from patients having cardiac lesions which impact the pulmonary circulation in distinct ways, as well as experimental studies, asking how altered hemodynamics impact the risk of develop...

BACKGROUND AND AIMS Carotid artery plaques with vulnerable plaque components are related to a higher risk of cerebrovascular accidents. It is unknown which factors drive vulnerable plaque development. Shear stress, the frictional force of blood at the vessel wall, is known to influence plaque formation. We evaluated the association between shear stress and plaque components (intraplaque haemorr...

INTRODUCTION Enlargement of a pre-existing intracranial aneurysm is a well-established risk factor of rupture. Excessive low wall shear stress concomitant with turbulent flow in the dome of an aneurysm may contribute to progression and rupture. However, how stress conditions regulate enlargement of a pre-existing aneurysm remains to be elucidated. RESULTS Wall shear stress was calculated with...

In this study the performance of three macro-models in predicting the nonlinear response of different walls is investigated. The macro-models used are: Equivalent Beam Model, Multiple Vertical Line Element Model and a shear panel model developed by Massone et al. (2006). The walls are classified as slender, intermediate, and squat walls according to their shear-span ratio. First, three single w...

The finite element method (FEM) can be applied to practically analyze the tall buildings in which the shear walls are used to resist the lateral loads. Accordingly, a variety of displacement and strain-based as well as frame macro elements have been proposed for analysis of the tall buildings. With respect to application of the lower order plane stress elements, analytical problems may arise wi...

We theoretically investigate general properties of driven (sheared) colloidal suspensions in confinement, based on methods of classical density functional theory. In the absence of an exact closed (Smoluchowski-) equation for the one-particle density under shear, we formulate a set of general conditions for approximations, and show that a simple closure fulfills them. The exact microscopic stre...

Experimental results for quasi-static cyclic tests on reinforced concrete (RC) walls have shown that shear deformations can constitute a significant ratio of the total deformations when the wall is loaded beyond the elastic regime. For walls, which form a stable flexural hinge at their base, the ratio of shear to flexural deformations remains approximately constant over the entire range of impo...

BACKGROUND Unlike arteries, in which regionally distinct hemodynamics are associated with phenotypic heterogeneity, the relationships between endocardial endothelial cell phenotype and intraventricular flow remain largely unexplored. We investigated regional differences in left ventricular wall shear stress and their association with endocardial endothelial cell gene expression. METHODS AND R...