• Morton et al. examined the records of their practice patients who attended Emergency Departments in a twelve month period. Only 25% saw their GP before attending and 95% of these needed specialist interventions. On the other hand 75% of patients self-referred and only 33% of these required specialist intervention. • Cox et al. provide the first ever analysis of Specialist Palliative Care (SPC...

It is attempted to augment a coating resin with a bleaching effect to provide both short- and long-term whitening effects. Base resin containing sodium percarbonate (SPC) effectively bleached bovine teeth discolored by the Maillard reaction. SPC did not reduce Vickers hardness, but hardness in the hybrid material increased. The shear bonding strength of SPC-containing resin was low. No inflamma...

The quality consistence and machines’ utilization of a flexible manufacturing system (FMS) strongly depend on the statistical process control (SPC) and the correct fault diagnosis of equipments. An FMS can be modeled by the Colored Timed Petri Net (CTPN). However, the CTPN models of most FMSs lack the activities of the statistical process control (SPC) and fault diagnosis, and they lead to the ...

Recent developments in lipid mass spectrometry enable extensive lipid class and species analysis in metabolic disorders such as diabesity and metabolic syndrome. The minor plasma lipid class sphingosylphosphorylcholine (SPC) was identified as a ligand for lipid sensitive G-protein coupled receptors playing a key role in cell growth, differentiation, motility, calcium signaling, tissue remodelin...

BACKGROUND Human papillomavirus (HPV) causes >99% of cervical carcinomas and is associated with approximately 25% of head and neck squamous cell carcinomas (HNSCCs). The role of HPV infection in HNSCC development after a first diagnosis of cervical cancer is unknown. METHODS Using the National Cancer Institute's Surveillance, Epidemiology, and End Results data, the authors compared the risk o...

Although recent investigations have suggested that a Rho-kinase-mediated Ca2+ sensitization of vascular smooth muscle contraction plays a critical role in the pathogenesis of cerebral and coronary vasospasm, the upstream of this signal transduction has not been elucidated. In addition, the involvement of protein kinase C (PKC) may also be related to cerebral vasospasm. We recently reported that...

Characterizing interactions between multiple brain regions is important for understanding brain function. Functional connectivity measures based on partial correlation provide an estimate of the linear conditional dependence between brain regions after removing the linear influence of other regions. Estimation of partial correlations is, however, difficult when the number of regions is large, a...

AIMS Sphingosylphosphorylcholine (SPC) elicits vasoconstriction at micromolar concentrations. At lower concentrations (≤1 µmol/L), however, it does not constrict intrapulmonary arteries (IPAs), but strongly potentiates vasoreactivity. Our aim was to determine whether this also occurs in a systemic artery and to delineate the signalling pathway. METHODS AND RESULTS Rat mesenteric arteries and ...

Docetaxel has been used as first-line chemotherapy in advanced non-small cell lung carcinoma (NSCLC), but further extensive and effective application is prevented by drug resistance. MicroRNAs (miRNAs) have recently been identified as important posttranscriptional regulators, which are involved in various biological processes. The aim of this study was to identify microRNA expression profiles i...