In the course of W-tracer studies on the biological synthesis of lecithin in lung tissue slices, the ratio of fatty acid activity to glycerol activity in lecithin was higher than in the triglyceride fraction. It was suggested that the observed isotope distributions could be due to turnover of the fatty acid portion of lecithin without a corresponding synthesis and breakdown of the remainder of ...

Recently, increasing attention has been paid to lecithin/chitosan nanoparticles as colloidal drug delivery system showing the great potential to improve the permeation of encapsulated drug across various biological barriers [1, 2]. However, the overall poor stability of colloidal nanoparticles in an aqueous medium is a significant drawback in their development perspective. Therefore, the aim of...

The lecithin which is used in cardiolipin antigens for the sero-diagnosis of syphilis is extracted from beef heart tissue or egg yolk by the methods of Pangborn, Maltaner, Tompkins, Beecher, Thompson, and Flynn (1951). The product is actually a mixture of individual lecithins containing chiefly unsaturated but also some saturated fatty acids, the composition varying with the source and method o...

Ketorolac tromethamine (KT) containing microemulsion-based gels (MBGs) have been formulated, based on the previous phase diagram studies, using a pharmaceutically acceptable surfactant (soybean lecithin; Epikuron 200) and oil (isopropyl myristate; IPM) and the effect of formulation variables on the release profile of the drug from MBGs through intact guinea pig skin and various artificial membr...

The incorporation of [2-3H]glycerol and lysolecithin labeled with [2-3H]glycerol into lecithin and its subspecies was investigated in epithelial and muscular layers of rat small intestine. The labeled compounds were administered in two wways: the intraduodenal injection and the injection into femoral vein. The incorporation of glycerol into lecithin was distinctly higher in epithelial layer tha...

Lecithin was fi rst isolated from egg yolk in the 1850’s. The Greek word for egg yolk, lekithos, is the basis for the name lecithin. Lecithin has a reputation for being “brain food” because of its high concentration of phosphatidyl choline, a nutrient which supports primary brain functions including memory, thought, and muscular control. Phosphatidyl choline is the biological precursor to acety...

Surface potentials of mixed monolayers of dicetyl phosphate and eicosanyl trimethylammonium bromide (1:1) were the same on subsolutions of 0.02 M NaCl or 0.01 M CaCl(2), which indicated that ionic phosphate does not interact with Ca(++) in the presence of a neighboring trimethylammonium group. Surface potential-pH plots of dicetyl phosphate, and of dipalmitoyl, egg, and dioleoyl lecithins showe...

The biliary excretion rates of bile acid, lecithin, and cholesterol were measured in unanesthetized dogs after interruption of enterohepatic circulation and during infusions of sodium taurocholate, sodium glycocholate, sodium dehydrocholate, SC2644 (a bicyclic organic acid with high choleretic potency), and secretin. Both lecithin output and cholesterol output were directly related to bile acid...

Fluorescence polarization measurements of microviscosity (apparent viscosity within the hydrophobic center of lipid bilayers) of amniotic fluid correlate well with lecithin/sphingomyelin ratios determined by thin-layer chromatography. In addition to lecithin, phosphatidylglycerol and phosphatidylinositol are important for determining fetal lung maturity, but the lecithin/sphingomyelin ratio giv...