Muscadine grape skin extract (MSKE) is derived from muscadine grape (Vitis rotundifolia), a common red grape used to produce red wine. Endoplasmic reticulum (ER) stress activates the unfolded protein response (UPR) that serves as a survival mechanism to relieve ER stress and restore ER homeostasis. However, when persistent, ER stress can alter the cytoprotective functions of the UPR to promote ...

introduction: citrus fruits, which belong to the family of rutaceae are one of the main fruit tree crops grown throughout the world. although sweet orange (citrus sinensis) is the major fruit in this group accounting for about 70% of citrus output.citrus fruits are well – appreciated fortheir refreshing juice and health benefits.the health benefits of citrus fruits are linked to the high amount...

The dermaseptin peptides, mainly derived from the skin secretions of Hylidae frogs, belong to a superfamily of antimicrobial peptides and exhibit diverse antimicrobial and anticancer activities with low cytotoxicity. Here, we reported a novel dermaseptin peptide, from the South American orange-legged leaf frogs, Pithecopus (Phyllomedusa) hypochondrialis, processing the shortest peptide length, ...

Thyroid dermopathy is an uncommon manifestation of autoimmune thyroid disease. About 0.5%-4.3% of patients with history of thyrotoxicosis and 15% of patients with severe Graves' ophthalmopathy have this cutaneous manifestation. However thyroid dermopathy is almost always associated with ophthalmopathy (96%) and sign and symptoms of hyperth-yroidism. The diagnosis of thyroid dermopathy is based ...

An initial local lesion in the skin together with a regional lymphadenitis, sometimes with formation of sterile pus following a scratch or bite by a cat is now being described as a separate disease entity. Originally recognised by Fosllay and Debre (Editorial, 1952) independently, a large number of cases has now been reported, mainly from France and U.S.A. and occasionally from other European c...

Agent Orange is at the core of an ongoing controversy involving veterans organizations that want the Federal govenment to complete a study intended to examine possible lasting health effects of exposure to this herbicide during the Vietnam War. Many Vietnam veterans are quite concerned that various health problems they have suffered may be associated with exposure to Agent Orange in Vietnam. Th...