Abstract Background The emergence of immune checkpoint inhibitors (ICI’s) in the past decade has proven transformative area immuno-oncology. PD-1 / PD-L1 axis been particularly well studied and monoclonal antibodies developed to block either receptor (anti PD-1) or its associated ligand PD-L1) can generate potent anti-tumour immunity certain tumour models. However, many “immune cold” tumours re...

Organic Sonosensitizers A new strategy of organic sonosensitizers based on boron-doped acenethiophene scaffolds is presented by Zhenqi Jiang, Frieder Jäkle, Xiaodong Yin, and co-workers in article number 2206594. Ultrasound irradiation water-dispersible nanoparticle BAnTh-NPs BTeTh-NPs can efficiently generate •OH while exhibiting low phototoxicity. In vitro vivo studies indicate that acenethio...

Abstract Background Pancreatic cancer remains a significant therapeutic challenge and its poor prognosis has remained relatively unchanged for the past 40 years. tumours are highly desmoplastic impenetrable lesions in which both gas mass transfer is severely compromised. This leads to development of hypoxia within tumour this compromises approaches that rely on cytotoxic reactive oxygen species...

There are increasing data showing that sonodynamic therapy (SDT), which refers to a synergistic effect of drugs and ultrasound, is a promising new modality for cancer treatment. However, few clinical data on SDT have been published. One reason is the lack of suitable drugs for clinical SDT use. Recently a new sonosensitizing agent has been developed by SonneMed, LLC, referred to as SF1. In this...