Choroidal neovascularization (CNV) is characterized by abnormal blood vessels growing from the choroid. Current remedies for CNV have not shown favorable therapeutic efficacy. It is urgent to identify and develop more safe and potent anti-CNV agents via multiple technologies. We previously showed that the natural product naringenin attenuated CNV. However, naringenin has poor water solubility a...

Exposure to particulate matter (PM), a major form of air pollution, can induce oxidative stress and inflammation and may lead to many diseases in various organ systems including the skin. Eupafolin, a flavonoid compound derived from Phyla nodiflora, has been previously shown to exhibit various pharmacological activities, including antioxidant and anti-inflammatory effects. Unfortunately, eupafo...

Orbifloxacin (ORBI) is a widely used antimicrobial drug of the fluoroquinolone class. In the official pharmaceutical compendia the existence of polymorphism in this active pharmaceutical ingredient (API) is reported. No crystal structure has been reported for this API and as described in the literature, its solubility is very controversial. Considering that different solid forms of the same API...

Introduction: Tooth enamel mineral loss is influenced by its solubility product value, which is fundamental to the understanding of de- and remineralization resulting from a carious or erosive challenge. Published pKsp values for human enamel and hydroxyapatite range from 110 to 126 suggesting a heterogeneous nature of enamel solubility. However, this range of values may also result from the va...

introduction: solubility of mineral trioxide aggregate (mta) is an important characteristic that affects other properties such as microleakage and biocompatibility. distilled water (dw) has previously been used for solubility tests. this experimental study compared the solubility of mta in dw, synthetic tissue fluid (stf) and new simulated plasma (sp). methods and materials: in this study, 36 s...

objective: application of chemical solvents especially in problematic canals is usually a part of the retreatment process.this study was performed to compare the solubility of gutta- percha and resilon in chloroform and to find the effect of sample thickness as well as the time of shaking on their solubility. materials and methods: specific weight of resilon and gutta-percha was placed in a sam...

blends of sorghum and soybean flours were processed in a co-rotating twin screw extruder to prepare expanded product. response surface methodology (rsm) was used to study the effect of soya level (sl), feed moisture (fm), barrel temperature (bt) and screw speed (ss) on extruder system parameters and physical properties of the extrudate. response variables were product temperature (pt), motor to...

Purpose: To develop rosuvastatin calcium-loaded self-nanoemulsifying powder for improved oral delivery of the drug. Methods: Solubility study was carried out in different oils, surfactants and co-surfactants. Based on the solubility study, liquid formulations were prepared using LAS/Capryol 90: Maisine 35-1 as oil phase and Tween 20 with Lutrol E400 as surfactant mixture (Smix). The liquid form...

A novel chitosan-based biopolymer dye possessing antibacterial properties was synthesized by reaction of O-carboxymethyl chitosan and Acid Red GR. The synthesized materials were characterized by Fourier transform infrared spectroscopy (FTIR), degree of substitution (DS), X-ray photoelectron spectroscopy (XPS), thermogravimetric analysis (TG), X-ray diffraction (XRD), water solubility test, anti...

Ketoconazole (KET), an imidazole derivative with well-known antifungal properties, is lipophilic and practically insoluble in water, therefore its clinical use has some practical disadvantages. The aim of the present study was to investigate the influence of PAMAM-NH(2) and PAMAM-OH dendrimers generation 2 and generation 3 on the solubility and antifungal activity of KET and to design and evalu...