Background and objectivesEpilepsy is a neural disorder that occurs because of disruption in conductions various parts the brain mainly characterized by seizures, pensive gaze, involuntary mimics, contractions, meaningless speeches, repetitive movements, loss consciousness. The serious side effects conventional drug delivery systems due to high applied doses, low transition rates brain, limitati...

Previously, it was shown that microneedle-mediated transcutaneous immunization with plasmid DNA can potentially induce a stronger immune response than intramuscular injection of the same plasmid DNA. In the present study, we showed that the immune responses induced by transcutaneous immunization by applying plasmid DNA onto a skin area pretreated with solid microneedles were significantly enhan...

Drug loaded dissolving microneedles (DMNs) fabricated with water soluble polymers have received increasing attentions as a safe and efficient transdermal drug delivery system. Usually, to reach a high drug delivery efficiency, an ideal drug distribution is gathering more drugs in the tip or the top part of DMNs. In this work, we introduce an easy and new method to introduce a bubble with contro...

The aim of this study was to fabricate polymeric microneedles, loaded with macrolides (erythromycin, azithromycin), using hyaluronic acid and polyvinyl pyrollidone. These microneedles were fabricated a vacuum micromolding technique. integrity the microneedle patches studied by recording their morphologic features, folding endurance, swelling micro-piercing. Physicochemical characteristics diffe...

(1) Berkeley Sensor and Actuator Center – University of California, Berkeley. 497 Cory Hall, Berkeley, CA 94720-1774 (2) Department of Bioengineering – University of California, Berkeley. 459 Evans Hall, Berkeley, CA 94720-1762 (3) Department of Mechanical Engineering – University of California, Berkeley. Berkeley, CA 94720-1740, USA -Tel +1 510 642 9360, Fax +1 510 643 6637, Email liepmann@me....

Invasion of tumor cells into the surrounding connective tissue and blood vessels is a key step in the metastatic spread of breast tumors. Although the presence of macrophages in primary tumors is associated with increased metastatic potential, the mechanistic basis for this observation is unknown. Using a chemotaxis-based in vivo invasion assay and multiphoton-based intravital imaging, we show ...

BACKGROUND Microneedles provide a minimally invasive means to transport molecules into the skin. A number of specific strategies have been employed to use microneedles for transdermal delivery. OBJECTIVE The purpose of this study was to investigate the safety of two new digital microneedle devices (Digital Hand® and Digital Pro®; Bomtech Electronics Co., Ltd., Seoul, Korea) for the perforatio...