نتایج جستجو برای: snail

تعداد نتایج: 8109  

2015
Jeong Ae Park Dong Young Kim Young-Myeong Kim In-Kyu Lee Young-Guen Kwon Victoria Bautch

Vascular branching morphogenesis is activated and maintained by several signaling pathways. Among them, vascular endothelial growth factor receptor 2 (VEGFR2) signaling is largely presented in arteries, and VEGFR3 signaling is in veins and capillaries. Recent reports have documented that Snail, a well-known epithelial-to-mesenchymal transition protein, is expressed in endothelial cells, where i...

Journal: :The Journal of clinical investigation 2008
Kristina E Hoot Jessyka Lighthall Gangwen Han Shi-Long Lu Allen Li Wenjun Ju Molly Kulesz-Martin Erwin Bottinger Xiao-Jing Wang

TGF-beta and its signaling mediators, Smad2, -3, and -4, are involved with tumor suppression and promotion functions. Smad4-/- mouse epidermis develops spontaneous skin squamous cell carcinomas (SCCs), and Smad3-/- mice are resistant to carcinogen-induced skin cancer; however, the role of Smad2 in skin carcinogenesis has not been explored. In the present study, we found that Smad2 and Smad4, bu...

Journal: :Oncology reports 2016
Ichiro Ota Takashi Masui Miyako Kurihara Jong-In Yook Shinji Mikami Takahiro Kimura Keiji Shimada Noboru Konishi Katsunari Yane Toshiaki Yamanaka Tadashi Kitahara

Epithelial-mesenchymal transition (EMT) is a key process involved in the invasion and metastasis of cancer cells. Furthermore, EMT can induce a cancer stem cell (CSC)-like phenotype in a number of tumor types. We demonstrated that Snail is one of the master regulators that promotes EMT and mediates cancer cell migration and invasion in many types of malignancies including head and neck squamous...

2015
Asfar S. Azmi Irfana Muqbil Jack Wu Amro Aboukameel William Senapedis Erkan Baloglu Aliccia Bollig-Fischer Gregory Dyson Michael Kauffman Yosef Landesman Sharon Shacham Philip A. Philip Ramzi M. Mohammad

Here we demonstrate for the first time that targeted inhibition of nuclear exporter protein exportin 1 (XPO1) also known as chromosome maintenance region 1 (CRM1) by Selective Inhibitor of Nuclear Export (SINE) compounds results in reversal of EMT in snail-transduced primary human mammary epithelial cells (HMECs). SINE compounds selinexor (KPT-330) and KPT-185, leptomycin B (LMB as +ve control)...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2016
Javier Perez-Saez Theophile Mande Natalie Ceperley Enrico Bertuzzo Lorenzo Mari Marino Gatto Andrea Rinaldo

We report about field and theoretical studies on the ecology of the aquatic snails (Bulinus spp. and Biomphalaria pfeifferi) that serve as obligate intermediate hosts in the complex life cycle of the parasites causing human schistosomiasis. Snail abundance fosters disease transmission, and thus the dynamics of snail populations are critically important for schistosomiasis modeling and control. ...

2015
YAN ZHANG NINA FAN JING YANG

The aim of the present study was to investigate the expression and clinical significance of hypoxia-inducible factor 1α (HIF-1α), Snail and E-cadherin in ovarian cancer. The expression levels were assessed in a number of ovarian cancer cell lines and ovarian cancer tissues, and correlations between the expression of the three proteins and clinical pathological factors were analyzed. Transwell a...

Journal: :physiology and pharmacology 0
jafar vatanparast mahyar janahmadi neuroscience research center and department of physiology, faculty of medicine, shaheed beheshti medical sciences houri sepehri ali haeri-rohani ali reza asgari

introduction: since organophosphorus compounds (op) are toxic and designed to destroy insects and pest species, there are many hazards associated with their use. although, the main target site of these compounds is acetylcholinesterase (ache), however it has become increasingly evident that ops have also other direct effects on cellular processes. in the present study, the effects of low concen...

ژورنال: مجله علمی پژوهان 2014

Introduction: As seasonal turbidity is one of the major challenges in drinking water supply consequently, take an appropriate method to provide standards range is necessary. This study aimed to determine the effect of Snail shell as a coagulant aid in the removal of turbidity in aqueous environments using electrocoagulation process through aluminum electrodes. Methods: This experimental stud...

Journal: :Journal of cell science 2004
Hector Peinado Faustino Marin Eva Cubillo Hans-Juergen Stark Norbert Fusenig M Angela Nieto Amparo Cano

The transcription factors Snail and E47 are direct repressors of E-cadherin, with both inducing a full epithelial-mesenchymal transition and invasive behaviour in vitro when expressed in the prototypic epithelial MDCK cell line. The role of these repressors in the invasive process and in other tumorigenic properties is, nevertheless, still poorly understood. However, organotypic cultures and in...

2017
Jin Zou Yanhua Liu Bingong Li Zeqi Zheng Xuan Ke Yanqin Hao Xuelian Li Xingxing Li Fuyou Liu Zhiyong Zhang

Endothelial-to-mesenchymal transition (EndMT) mainly exists in cardiovascular development and disease progression, and is well known to contribute to cardiac fibrosis. Recent studies indicated that autophagy also participates in the regulation of cardiac fibrosis. However, the precise role of autophagy in cardiac fibrosis and the underlying molecular mechanism remain unclear. The present study ...

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