PURPOSE Claudin-1 is a tight junction protein described in normal tissues as well as in malignancies. We aimed to assess the diagnostic or prognostic significance of claudin-1 expression in renal cell carcinoma and to correlate the expression of claudin-1 with clinical, histopathologic, and prognostic parameters in renal cell carcinoma. EXPERIMENTAL DESIGN A tissue microarray was constructed ...

background: opticin, as a member of small leucine rich proteoglycans (slrps), mainly expressed in human eyes. it is also expressed in human brain, ligament, liver and skin, but at lower levels than the eyes. in the present study, expression of opticin was studied in a variety of human cancer cell lines. materials and methods: in this basic study, human cancer cell lines including, a-172 (brain ...

Renal cell carcinoma (RCC) metastasis to duodenum is very rare and only a few case reports are available in the literature. We here reported a patient with solitary duodenal metastasis presented with melena six years after right nephrectomy. The patient underwent upper gastrointestinal endoscopy showing ulcerative mass at the second portion of duodenum and biopsy of this mass was consistent wit...

Bowel intussusception is rare in adults and usually driven by an underlying pathological process affecting the bowel. Renal cell carcinoma (RCC) most common type of kidney cancer its disease course, depending on initial histology stage, can metastasize to adrenal glands, lungs, bones, brains contralateral that be challenging follow. We present case a patient with history radical left nephrectom...

PURPOSE We diagnosed the subtypes of renal cell carcinoma on needle core biopsies using a combination of histopathology and a molecular diagnostic algorithm. MATERIALS AND METHODS Core biopsies were taken of renal tumors following nephrectomy. RNA was extracted and quantitative real-time polymerase chain reaction was performed for 4 gene products to differentiate among renal cell carcinoma su...

On November 23, 2015, the US Food and Drug Administration (FDA) approved nivolumab for treatment of metastatic renal cell carcinoma (RCC), thus opening a new era immunotherapy this tumor. This review summarizes 5-year experience studying using in RCC patients.

1 Wagner B, Patard JJ, Mejean A et al. Prognostic value of renal vein and inferior vena cava involvement in renal cell carcinoma. Eur. Urol. 2009; 55: 452–9. 2 Moch H, Artibani W, Delahunt B et al. Reassessing the current UICC/AJCC TNM staging for renal cell carcinoma. Eur. Urol. 2009; 56: 636–43. 3 Kim HL, Zisman A, Han KR et al. Prognostic significance of venous thrombus in renal cell carcino...

The incidence and mortality rate of renal cell carcinoma (RCC) have been significantly increasing; however, the mechanisms involved in RCC development and progression are unclear. In this study, we found that miR-28-5p was decreased in RCC tumor specimens and several renal carcinoma cell lines. By using a combination of luciferase reporter assays and western blotting, we identified RAP1B, a Ras...

Background: Bleeding from small bowel neoplasms account for 1–4% of cases of upper gastrointestinal haemorrhage. Renal cell carcinoma constitutes 3% of all adult malignancies and often presents insidiously. Consequently 25–30% of patients have metastases at the time of diagnosis. Gastrointestinal bleeding from renal cell carcinoma metastases is an uncommon and under-recognised manifestation of ...