Primary breast cancer fairly infrequently occurs in ectopic breast tissue, and primary ectopic breast cancer of the vulva is particularly rare. Only 26 cases have been published in the English-language literature, and there has been no report of primary breast carcinoma of the vulva in Japan. We report a rare case of primary ectopic breast cancer of the vulva that was treated with local excisio...

BACKGROUND Thick melanomas (TM) ≥4 mm have a high risk for nodal and distant metastases. Optimal surgical management, prognostic significance of sentinel node biopsy (SLNB), and benefits of interferon (IFN) for these patients are unclear. As a continuum of increasing tumor thickness is placed into a single TM group, differences in biologic and clinical behavior may be lost. The purpose of this ...

Abstract Objective To describe tattoo ink marking of axillary lymph nodes (TIMAN) and the elements leading to successful removal at sentinel node biopsy (SLNB). Methods An IRB-approved retrospective image review was conducted breast cancer patients who underwent SLNB after TIMAN from February 2013 August 2017, noting patient tattooed (TLN) features, initial type, time surgery, if TLN identified...

Recent approval of adjuvant anti-PD1 therapy for patients with pathologic stage IIB/C cutaneous melanoma has led to questioning whether sentinel lymph node biopsy (SLNB) is necessary clinical disease. We sought evaluate the prognostic significance SLNB in across T-stages using logistic regression and propensity matching, a technique that not been utilized previously examine this issue. Immune c...

Abstract Aim To highlight delays in the malignant melanoma (MM) pathway for patients undergoing a Wide Local Excision (WLE) and Sentinel Lymph Node Biopsy (SLNB). Aiming to evaluate if Trust standards are met, provide 31-day clock from time of clinic discussion WLE SLNB, date operation. In particular, comparing pre- (2019) post-COVID (2022) waiting times. Method Retrospective data collection wi...

BACKGROUND The benefits of sentinel lymph node biopsy (SLNB) for breast cancer patients with histologically negative axillary nodes, in whom axillary lymph node dissection (ALND) is thereby avoided, are now established. Low false negative rate, certainly with blue dye technique, mostly reflects the established high inherent accuracy of SLNB and low axillary nodal metastatic load (subject to pat...

BACKGROUND In patients with recurrent or second primary ipsilateral breast cancer, axillary staging is the key factor in locoregional control and a strong prognostic characteristic. The efficient evaluation of lymphatic drainage of re-sentinel lymph node biopsies (re-SLNBs) has remained a challenge in the management of ipsilateral primary or recurrent breast cancer patients who are clinically l...

Sentinel lymph node biopsy (SLNB) is currently the suggested axillary staging procedure in patients with early-stage breast cancer (BC) and usually requires intraoperative frozen-section (FS) examination of the removed nodes. However, other techniques, such as touch imprint cytology (IC), real-time reverse transcriptase-polymerase chain reaction and rapid cytokeratin immunostaining on FS may be...

CONTEXT The 7th (2009) edition of the AJCC melanoma staging system incorporates tumor (Breslow) thickness, MR, and ulceration in stratifying T1 primary melanomas. Compared to the prior 6th (2001) edition, MR has replaced CL for thin melanomas. OBJECTIVE We sought to identify and report differences of the classification of thin melanomas as well as outcome of SLNB in patients according to the ...

PURPOSE Tumor response to neoadjuvant chemotherapy (NAC) may adversely affect the identification and accuracy rate of sentinel lymph node biopsy (SLNB). This study was conducted to evaluate the feasibility of SLNB in node-positive breast cancer patients with negative axillary conversion after NAC. MATERIALS AND METHODS Ninety-six patients with positive nodes at presentation were prospectively...