The pineal hormone Melatonin plays an important role in the regulation of the circadian sleep/wake cycle, mood, and perhaps immune functions, carcinogensis and reproduction. The human circadian rhythm of melatonin release from the pineal gland is tightly synchronized with the habitual hours of sleep. Peri- and postmenopausal women often complain of difficulties initiating and/or maintaining sle...

background: coronary artery bypass grafting surgery (cabg) and precutaneous transluminal coronary intervention (pci) are safe and effective in the treatment of coronary artery disease. the aim of this study was to determine and compare anxi­ety, self efficacy expectation and perceived social support between cabg patients and pci patients referral to receiving car­diac rehabilitation programs. m...

coronary artery perforation is a rare, but potentially serious, complication of percutaneous coronary intervention and is associated with a high incidence of death, q-wave myocardial infarction, and emergency coronary bypass surgery. management is different but requires prompt recognition and treatment. we describe a case of coronary perforation only after guidewire removal and also review the ...

An institutionalised 13 year old girl with psychomotor retardation suffered from an irregular sleep-wake pattern. Multiple measurements of urinary sulphatoxy-melatonin (aMT6) concentrations were abnormally low, without any significant day-night differences. Administration of exogenous melatonin (3 mg) at 18:00 resulted in increased nocturnal urinary aMT6 concentrations and improvements in her s...

aneurysms of the left main coronary artery are exceedingly rare clinical entities, encountered incidentally in approximately 0.1% of patients who undergo routine angiography. the most common cause of coronary artery aneurysms is atherosclerosis. angiography is the gold standard for diagnosis and treatment. depending on the severity of the coexisting coronary stenosis, patients with left main co...

The pineal hormone melatonin is able to shift the timing of circadian rhythms, including the sleep-wake cycle, and to promote sleep. Melatonin agonists with similar properties have therapeutic potential for the treatment of circadian rhythm sleep disorders. Depression is specifically targeted by agomelatine, which is also a serotonin-2C (5-HT(2C)) antagonist.

Fifteen children (most of whom were neurologically multiply disabled) with severe, chronic sleep disorders were treated with 2 to 10mg of oral melatonin, given at bedtime. Nine had fragmented sleep patterns, three had delayed sleep onset and three others had non-specific sleep disturbance of unclear aetiology; all had failed to respond to conventional management. Nine patients had ocular or cor...

Children with neurological and developmental disorders often experience chronic sleep disturbances. Melatonin has been commonly prescribed because of its hypnotic properties. However, trials have had conflicting results. Therefore, researchers assessed the effectiveness of melatonin in treating severe sleep problems in children with neurodevelopmental disorders. A randomised double blind placeb...

Abstract: Coronary artery disease (CAD) is a multifactorial problem. Although hyperlipidemia (HLP), diabetes (DM), and hypertension (HTN) are known as the familial and cardiac risk factors, CABG is rare in the several members of a family. We reported the six members of a family who presented with MI and/or advanced angina pectoris during the 6 years. CABG(Coronary artery bypass graft) considere...

Positive symptoms in schizophrenia decrease the requirement for REM sleep and reduce its pressure, while negative symptoms increase the need for REM sleep. This need cannot be satisfied because REM sleep in schizophrenia is functionally insufficient. This insufficiency may relate to the decreased melatonin level. Melatonin treatment restores REM-sleep functional efficiency in patients with diff...