We have studied arterial PO2, PCO2, and hydrogen ion and electroencephalogram during sleep in 10 patients with stable severe chronic respiratory failure. As a group the patients slept badly. Sleep was associated with a worsening of hypoxia and no significant change in PCO2 and H+. Two patients were restudied, receiving oxygen therapy overnight. Both had improved sleep but one, who had an intact...

ATTENTION-DEFICIT/HYPERACTIVITY DISORDER (ADHD) IS AMONG THE MOST COMMON OF THE PSYCHOLOGICAL DISORDERS AFFECTING SCHOOL-AGED CHILDREN, WITH PREVALENCE ESTIMATES RANGING FROM 4% TO 12%.1 The cardinal features of ADHD include inattention, hyperactivity, and impulsivity. The pathophysiology of ADHD is not yet well understood but may involve abnormal functioning of dopaminergic, glutamatergic, and...

OBJECTIVE The aim of this study was to evaluate the sleep breathing patterns and to detect the eventual presence of periodic leg movements (PLMs) in patients affected by Angelman syndrome (AS). METHODS Ten children with AS were recruited to participate in the study; the clinical diagnosis was confirmed by the genetic analysis (maternal 15q deletion, uniparental paternal disomy, or mutation of...

Exposure to high altitude imposes significant strain on cardiopulmonary system and the brain. As a consequence, sojourners to high altitude frequently experience sleep disturbances, often reporting restless and sleepless nights. At altitudes above 3,000 meters (9,800 ft) almost all healthy subjects develop periodic breathing especially during NREM sleep. Sleep architecture gradually improves wi...

Recent reports have suggested that altered quality of life and well-being are reported by patients with sleep-related breathing disorders (SRBD). There seems to be no data available in the literature on factors underlying these behavioural consequences. In this study, health-related quality of life (HRQL) scores were examined in SRBD patients in order to establish which factors are implicated i...

The spectrum of breathing events during sleep in patients with obstructive sleep apnoea syndrome (OSAS) after the abolition of obstructive apnoeas has been extensively studied in tracheostomized patients, but has received much less attention in patients submitted to continuous positive airway pressure (CPAP). We analysed the breathing pattern during sleep in forty patients while CPAP was admini...

Sleep apnea is a serious and severely under-diagnosed sleep-related respiration disorder characterized by repeated disrupted breathing events during sleep. It diagnosed via polysomnography which an expensive test conducted in sleep lab requiring experts to manually score the recorded data. Since symptoms of are often ambiguous, it difficult for physician decide whether prescribe polysomnography...

OBJECTIVES In this study, we looked at the effect of hypercapnia on sleep architecture and breathing. We characterized the effect of hypercapnia on duration, frequency, and latency of NREM and REM sleep. We described state-specific patterns of breathing as well. This study is relevant to understand possible treatments for sleep disordered breathing. METHODS Four cats were studied during 3-hou...

Studies have consistently shown that sleep apnea patients have high accident rates, but the generalizability of the association beyond clinic populations has been questioned. The goal of this investigation was to determine if unrecognized sleep-disordered breathing in the general population, ranging from mild to severe, is associated with motor vehicle accidents. The sample comprised 913 employ...

CONTEXT Distinctive diagnostic classification schemes for insomnia diagnoses are available, but the optimal insomnia nosology has yet to be determined. OBJECTIVES To test the reliability and validity of insomnia diagnoses listed in the American Psychiatric Association's DSM-IV-TR and the International Classification of Sleep Disorders, second edition (ICSD-2). DESIGN Multitrait-multimethod ...