Histiocytic necrotizing lymphadenitis, Kikuchi-Fujimoto's Disease (KFD), is a condition rarely associated with systemic lupus erythematosus (SLE). The diagnosis of KFD can precede, postdate or coincide with the diagnosis of SLE. Lymphadenopathy is a common clinical presentation of KFD and SLE, and is histologically indistinguishable in both conditions. We describe two cases of KFD associated wi...

Cohort studies of survival in systemic lupus erythematosus (SLE) often have been limited by methodologic problems. In studies of inception cohorts of patients followed since 1980, survival at 5 years has exceeded 90%. These estimates are generally higher than survival estimates from earlier studies, suggesting that short-term survival in SLE has improved. There is less evidence to support major...

Systemic lupus erythematosus (SLE) is a clinically and serologically complex disease that demonstrates clinical, epidemiological and genetic differences among racial and ethnic groups. Some autoantibodies are useful for diagnosis of the illness. Others are clinically important because of associations with a particular manifestation of SLE. Antibodies to RNA helicase A (anti-RHA) comprise a newl...

Neuropsychiatric manifestations of systemic lupus erythematosus (SLE) are well documented and recently reviewed. As many as 14% to 75% of patients with SLE eventually develop various degrees of neuropsychiatric manifestations. It is relatively rare, however, for patients with SLE to have such manifestations initially. According to a retrospective study of 140 patients with SLE, only 5 patients ...

Systemic lupus erythematosus (SLE) is one of the most common autoimmune diseases. Here, we present a special surgical case of mitral stenosis with SLE. Mitral valve replacement was performed, and the postoperative course was uneventful. Pathohistological findings of the mitral valve showed chronic inflammation, proliferative fibrous change. The postoperative course seemed to be uneventful. But ...

BACKGROUND Systemic lupus erythematosus (SLE) is associated with premature atherosclerosis and vascular stiffening. Whether SLE alters left ventricular (LV) structure and function in the absence of valvular and clinical coronary artery disease is unknown. METHODS AND RESULTS SLE patients without clinical or echocardiographic evidence of valvular or coronary disease were age and gender matched...

Introduction. Systemic lupus erythematosus (SLE) is one of the systemic autoimmune diseases characterized by the polyclonal autoantibody production. The human homologue of the mouse double minute 2 (MDM2) is well known as the negative regulator of p53. MDM2 has been reported to be overexpressed in SLE animal model and to promote SLE. Since abnormally expressed proteins can induce autoimmune res...

INTRODUCTION Neuropsychiatric systemic lupus erythematosus (NPSLE) shows some similarities to neuroBehçet\'s disease (NBD). AIM OF THE WORK to investigate and compare the psychiatric manifestations in a cohort of patients of systemic lupus erythematosus (SLE ) versus Behcet's Disease (BD). Also, a comparison of MRI brain findings in SLE patients and BD patients presented with psychiatric diso...

UNLABELLED The objective of the study was to investigate whether subclinical hypothyroidism is a risk factor for a delayed clinical complete response in patients with SLE. This study included 363 patients with SLE classified according to the ACR classification criteria. These patients were divided into three groups: those who had subclinical hypothyroidism, a euthyroid state, and clinical hypot...

BACKGROUND To study the oxygen uptake efficiency and determine usefulness of submaximal parameters of oxygen uptake in systemic lupus erythematosus associated pulmonary arterial hypertension (SLE PAH) on performing a cardiopulmonary exercise test (CPET). METHODS CPET was performed in 21 SLE PAH patients, equal number of idiopathic pulmonary arterial hypertension (IPAH) patients and controls. ...