intestinal stem cells (iscs) are a group of rare cells located in the intestinal crypts which are responsible for the maintenance of the intestinal homeostasis and intestinal regeneration following injury or inflammation. lineage tracing experiments in mice have proven that iscs can repopulate the entire intestinal crypt. it is noteworthy that in such experiments, only a subset of intestinal cr...

background & aim: low back pain is broadly documented as one of the most widespread pathologies in the advanced domain. although the reasons of low back pain are uncountable, it has been meaningfully related to intervertebral disc degeneration. present therapies for intervertebral disc (ivd) degeneration such as physical therapy and spinal fusion reduce symptoms' severity, but do not treat the ...

BACKGROUND Due to the genetic relationship to humans, porcine stem cells are a very important model system to investigate cell differentiation, associated cell signaling pathways, and cell fate. Porcine skin derived stem cells have been isolated from mid-gestation porcine fetus recently. To our knowledge, stem cells from the skin of the adult porcine organism have not been isolated until now. H...

BACKGROUND The regenerative capacity of the skin, including the continuous replacement of exfoliated cells and healing of injuries relies on the epidermal stem cells and their immediate cell descendants. The relative contribution of the hair follicle stem cells and the interfollicular stem cells to dermal wound healing is an area of active investigation. Recent studies have revealed that the sm...

Background: The number of patients suffering from diabetic ulcers has been increased in recent years and the current therapies have faced failure. This study aimed to investigate the effects of Wharton’s jelly stem cells (WJMSCs) on the diabetic wound in an animal mode. Methods: During this laboratory experimental study carried out in Skin and Stem Cells Research Center from March 2021 to Nove...

Articles should focus on stem cell biology and may include the following topics: Stem cell properties § § Types, including hematopoietic stem cells, embryonic stem cells, mesenchymal stem cells and induced pluripotent stem cells, plasticity and immunophenotype. Stem cell biology § § Microenvironment niches, including bone marrow and fetal liver, gene regulation including that of transcription f...

stem cell research has obtained much prominence in recent years for its therapeutic potential in dealing with serious diseases, many of which are essentially incurable by routine therapies. mesenchymal stem cells with pluripotency and immunomodulatory properties are suitable candidates for tissue engineering and regenerative medicine. today, nanofibrous scaffolds are widely used in tissue engin...

objective(s): to investigate the effect of cinnamaldehyde and eugenol on the telomere-dependent senescence of stem cells. in addition, to search the probable targets of mentioned phytochemicals between human telomere interacting proteins (tips) using in silico studies. materials and methods: human adipose derived stem cells (hascs) were studied under treatments with 2.5 µm/ml cinnamaldehyde, 0....

embryonic stem cells (escs) are originally derived from the icm of blastocysts and are characterized by their ability to self-renew and their pluripotencies. only a few reports have been published on esc isolations and line establishment in animals, even fewer in horses. however, it is still important to isolate equine escs for animal biotechnology and therapeutic applications. in the present s...

the human placenta has long been the subject of scientific interest due to the important roles which it performs during pregnancy in sustaining the fetus and maintaining fetomaternal tolerance. more recently, however, researchers have begun to investigate the possibility that the placenta’s utility may extend beyond fetal development to act as a source of cells with clinically relevant properti...