Merkel cell carcinoma (MCC) is an uncommon but highly malignant neuroendocrine tumor of the skin. MCC can metastasize, but involvement of the central nervous system is rare. Here, we report a case of rapidly progressing metastatic MCC to the clivus and bilateral cavernous sinus in an immunocompromised patient. This case is unique in that it is the first case report showing MCC metastasis to the...

Facial metastasis from colorectal cancer is very unusual. Herein, we report a 53-year-old man with history of colon cancer who was referred to our clinic because of an asymptomatic nodule on his chin for one year. Histopathologic examination of the nodule revealed metastatic adenocarcinoma, which was similar to that of the primary colon adenocarcinoma. The patient underwent radiotherapy for his...

Metastatic lesions to the clivus have been reported in various cancers including lung cancer, prostate carcinoma, skin melanoma, and hepatocellular carcinoma. There have been only a few reports of breast cancer presenting with isolated clival metastasis. We report a case of 35-year-old lady, who was known case of breast carcinoma presented with diplopia as the only sign of clival metastasis. Th...

A 52-year old man, chronic smoker for 20 years, presented at our department with skin nodule, firm, painful and ulcerated, localized in the trunk, rapidly grown for period of three months. Histological and immunohistochimical examination confirmed the lesion to be metastasis of lung adenocarcinoma. The patient underwent a CT scan of the abdomen and thorax, which revealed primytumor of the left ...

Hypernephroma is one of the most common visceral adenocarcinomas which metastasize to the head and neck. The metastasis may precede discovery of the primary or follow it. The most common sites of metastatic hypernephroma to the head and neck are the sinonasal tract, skin, cervical lymphatics, and mandible. Three cases of metastatic hypernephroma are presented and one of these is the first docum...

Early stage carcinoma of the tonsil is curable, and the incidence of systemic metastasis is very low and central nervous system involvement is very rare. A patient diagnosed with early stage tonsillar carcinoma treated with chemoradiation was followed by brachytherapy boost. One and half years after completion of treatment, the patient presented with disseminated metastasis to the skin, lung, l...