Background: Recently, the development of Parkinson's disease (PD) has been linked to a number of genetic risk factors, of which the most common is glucocerebrosidase (GBA) mutations. Methods: We investigated PD and Gaucher Disease (GD) patient derived skin fibroblasts using biochemistry assays. Results: PD patient derived skin fibroblasts have normal glucocerebrosidase (GCase) activity, whilst ...

The ability of β-cyclodextrin, hydroxypropyl-β-cyclodextrin, polyvinyl pyrrolidone and urea to influence the percutaneous absorption of meloxicam through isolated rat skin was evaluated. Carrier complex were prepared by kneading method in 1:1 and 1:2 in molar ratios for β-cyclodextrin and hydroxypropyl-β-cyclodextrin and in 1:1, 1:3 and 1:5 in weight ratios for polyvinyl pyrrolidone and urea. T...

Lipophilic ion-pair complexes of 3-dl-alpha-tocopherylcarbonyl-1-n-alkyl-pyridinium-cromolyn (TAP-CG) were designed to enhance the percutaneous absorption of cromolyn (CG), and the effect of n-alkyl chainlength of the ion-pair complexes on the CG permeation through hairless mouse skin was evaluated in vitro. The permeation rates of CG were examined in isopropyl myristate (IPM) suspension using ...

The aim of present study was to enhance topical permeation of clotrimazole gel preparation by using various permeability enhancers such as coconut oil, pistachio oil and sodium lauryl sulphate (SLS). Clotrimazole gel preparations were prepared and optimized by using three factor, five level central composite design. A second-order polynomial equation was generated in order to estimate the effec...

In this paper conjugated heat transfer in thermal entrance region through the sinusoidal wavy channel has been investigated. The fluid flow is assumed to be laminar, steady state, incompressible, and hydrodynamically fully developed. A constant heat flux is assumed to be applied on the outer edge of the channel wall. In this study the governing equations including continuity, momentum and energ...

This study investigates whether malathion, a widely used organophosphate insecticide, has its effects on cutaneous vasculature in healthy human volunteers through its anticholinergic activity or through the modulation of other, noncholinergic pathways. Acute, low-dose exposure to malathion (10 mg/ml for 5 h under occlusive dressing) caused a significant increase in cutaneous blood flux, monitor...

Recently, the development of Parkinson’s disease (PD) has Background: been linked to a number of genetic risk factors, of which the most common is glucocerebrosidase (GBA) mutations. We investigated PD and Gaucher Disease (GD) patient derived skin Methods: fibroblasts using biochemistry assays. PD patient derived skin fibroblasts have normal glucocerebrosidase Results: (GCase) activity, whilst ...

PURPOSE: Pannexin 3 (Panx3) is a gap junction protein. We have previously shown that Panx3 plays multiple channel functions: 1) as a hemichannel to regulate intracellular ATP/cAMP levels between cells and the extracellular space, 2) as an ER calcium channel to regulate calcium flux within the cell, and 3) a gap junction to exchange ions and small molecules between cells. However, the role of Pa...

PURPOSE: Pannexin 3 (Panx3) is a gap junction protein. We have previously shown that Panx3 plays multiple channel functions: 1) as a hemichannel to regulate intracellular ATP/cAMP levels between cells and the extracellular space, 2) as an ER calcium channel to regulate calcium flux within the cell, and 3) a gap junction to exchange ions and small molecules between cells. However, the role of Pa...