Inverted sinonasal papilloma (ISP) is a locally aggressive neoplasm associated with sinonasal squamous cell carcinoma (SNSCC) in 10% to 25% of cases. To date, no recurrent mutations have been identified in ISP or SNSCC. Using targeted next-generation sequencing and Sanger sequencing, we identified activating EGFR mutations in 88% of ISP and 77% of ISP-associated SNSCC. Identical EGFR genotypes ...

One Case of primary malignant lvmphuma of the Thyroid is presented this article. The primilry lym­phoma of the thvroid gland 1s very rare. All reports agree that the distinction clinically and grossly be­tween lymphoma and undifferentiated carcinoma is extremely difficult.  The (qnphoma of thyroid is often associated with Hashimoto disease. The treatment of the primary m.ilignar:t lymphoma of ...

Undifferentiated carcinoma merupakan subtipe KNF yang mempunyai titer antibodi EBV lebih tinggi daripada orang sehat. Efek karsinogenik melibatkan LMP-1 berhubungan dengan buruknya prognosis sedangkan p53 mutan memprediksi kekambuhan tumor. Penelitian ini menilai pengaruh dan pasien (Undifferentiated carcinoma). Studi analitik observasional cross-sectional di Laboratorium Patologi Anatomi RSUP ...

UNLABELLED The aim of the present study was to present data on frequency of thyroid cancer in Mures County (Romania) and border counties, a goiter endemic area, and to analyze its histopathological characteristics, over a 20 years period (1990-2009). MATERIALS AND METHODS Demographic, clinical and pathological data were obtained from database registries. Histological subtypes of thyroid cance...

OBJECTIVE To describe the clinico-pathologic manifestations of sinonasal malignancies, identify the contributing factors to delay in presentation and recommend ways of preventing them in a resource challenged environment. DESIGN A questionnaire based cross sectional descriptive study of patients with sinonasal malignancies between 2006 and 2011. SETTING Hospital based study at the Otorhinol...

Objectives To describe the presentation, work-up, and management of patients with metastatic renal cell carcinoma (RCC) to the sinonasal cavity and skull base, and to describe our current treatment algorithm of endoscopic surgical resection followed by radiation therapy. Design Retrospective review of two recent cases from our institution over a 1-year period, with a relevant review of the lite...

Forty-six cases of primary bronchogenic carcinoma occurring in patients with other unilateral pleuropulmonary diseases were studied. In 37 cases (80-4%) carcinoma developed in the previously healthy lung. All but one squamous-cell carcinoma and all of five undifferentiated small-cell carcinomas developed in the previously healthy lung while 7 of 15 adenocarcinomas were in the lung with impaired...