Hypertension is a cardiovascular disease that manifests itself with continuous increase in systemic arterial blood pressure and can lead to serious complications over time. It estimated 37% of hypertensive patients receive treatment one-third them are under control. Telmisartan an angiotensin receptor blocker used the hypertension. Uridine 5'-diphospho-glucuronyltransferase 1 (UGT1A1) gene enco...

AIMS The aim of this study was to investigate whether prolonged and dispersed myocardial contraction duration assessed by tissue Doppler imaging (TDI) may serve as risk markers for cardiac events (documented arrhythmia, syncope, and cardiac arrest) in patients with long QT syndrome (LQTS). METHODS AND RESULTS Seventy-three patients with genetically confirmed LQTS (nine double- and 33 single-m...

Patients with an oral squamous cell carcinoma (OSCC) often develop multiple malignant lesions. This report examined whether individual tumours developed in a patient show the same genetic alteration, such as p53 mutations. This case study describes three SCCs and three leukoplakias which developed simultaneously in a single 67-year-old Japanese man. A p53 mutation was detected in two of the thr...

Shaker potassium channels from Drosophila are composed of four identical subunits. The contribution of a single subunit to the inactivation gating transition was investigated. Channels carrying a specific mutation in a single subunit can be labeled in a heterogeneous population and studied quantitatively with scorpion toxin sensitivity as a selection tag. Linkage within a single subunit of a mu...

background: in order to deworm the ruminants especially of sheep in iran, consumption of benzimi­dazoles has more than 2 decades history and today farmers are using imidazothiazoles, macrocyclic lactones and mostly benzimidazole compounds (bzs) to treat infected farm animals. it has been demonstrated that the most common molecular mechanism leading to bzsresistance in haemonchus contortus is a ...

background: the recently reported resistance to antimalarials contributes to making the control of ma­laria more difficult. there is a need to evaluate the current antimalaria regimens to prevent this emerging problem. the aim of this study was to determine dihydrofolate reductase-thymidylate synthase gene mu­tation ( pvdhfr ) regarding antifulate resistance in plasmodium vivax . methods : from...

litter size is one of the most important economical traits in sheep breeding industry. in addition to minor genes, litter size is under the influence of major genes. bone morphogenetic protein 15 (bmp-15), a member of the transforming growth factor beta (tgf-ß) superfamily, which is specifically expressed in oocytes, plays a dramatic role in sheep prolificacy. reported mutations in this gene ca...

The COVID-19 infection is caused by the virus SARS-CoV-2. It a single stranded RNA hence has high mutation rate. In populous country like India, it can find large number of hosts to infect and thus undergo strong mutation. Indian variant B.1.617 undergone three form B.1.617.2 (double mutant) B.1.617.3 (triple mutant). declared Variant Concern due its increase transmissibility, immune escape, ef...

A single mutation leads to temperature-sensitive amber and ochre suppression in yeast. This mutation maps in or near the SUP4 gene on chromosome X.