A spectrophotometric method was developed for simultaneous determination of amlodipine (Aml) and valsartan (Val) without previous separation. In this method amlodipine in methanolic solution was determined using zero order UV spectrophotometry by measuring its absorbency at 360.5 nm without any interference from valsartan.Valsartan spectrum in zero order is totally overlapped with that of amlod...

trate, and Sulfate from Dried Urine Filter Paper Spots in a Pediatric Population, Nenad Blau, Ana Matasovic, Anna Lukasiewicz-Wedlechowicz, Claus W. Heizmann, and Ernst Leumann (Divisions of 1 Clinical Chemistry and Biochemistry and 2 Nephrology, University Children’s Hospital, Steinwiesstrasse 75, 8032 Zürich, Switzerland; * address for correspondence: University Children’s Hospital, Division ...

T HE POSSIBILITY OF DRUG intoxication frequently arises in patients admitted to the hospital in coma. Ingestion of salicylates by children and of barbiturates by adults are the most common causes. Since the introduction of glutethimide (2-ethyl-2-phenylglutarimide) in 1954, there have been increasing reports implicating this drug in drug intoxication. Since the clinical picture of glutethimide ...

Metallothionein (MT) has a dynamic role in cellular zinc metabolism. In order to determine the apoprotein thionein (T), an assay was developed. With this method tissue homogenates were treated with subtilisin to digest any T that might exist but MT could not be digested by subtilisin. MT was detected by cadmium-hemoglobin saturation method and T was determined as the difference of MT between sa...

Flow injection analysis (FIA) methods for the spectrophotometric determination of CO2 and SO2 in wines are described. The determination of CO2 is based on the colour change of a low capacity buffer (containing an acid-base indicator) due to the dissolved carbon dioxide. The determination of SO2 is based on the decoloration of malachite green by sulphur dioxide. Two FIA manifolds are presented; ...

in this research, rehydration behavior of dried figs was studied at different temperatures (25, 60, 70, 80, and 90°c). the rehydration kinetic was examined using the four most frequently used empirical models, namely, weibull, peleg, first-order, and exponential association models. the weibull model gave the highest coefficient of determination (r2) and the lowest values of root mean square err...

second order advantage of excitation-emission fluorescence matrix was applied for the simultaneous determination of ibuprofen and caffeine. the proposed method is based on the measurement of the native fluorescence and recording emission spectra of ibuprofen and caffeine in different excitation wavelengths. the mixture of these compounds was resolved by multivariate curve resolution coupled wit...

Rapid and simple method was developed for simultaneous determination of vitamins A and E contents in infant formula. Vitamins A and E were extracted by PDA-HPLC with reversed phase column using organic solvent, and their contents in Certified Reference Material (CRM) and infant formula were determined and compared with results of Food Standards Codex and AOAC method for evaluation of developed ...

Simultaneous spectrophotometric determination of salicylamide and paracetamol by H-point standard addition method (HPSAM) and partial least squares (PLS) calibration is described. The results showed that simultaneous determinations could be performed with the ratio 0.2:5–20:1 for salicylamide – paracetamol. A partial least – squares multivariate calibration method for the analysis of binary mix...