ceramide as a second messenger is a key regulator in apoptosis and cytotoxicity. ceramide-metabolizing enzymes are ideal target in cancer chemo-preventive studies. neutral sphingomyelinase (nsmase), acid ceramidase (acdase) and glucosyl ceramide synthase (gcs) are the main enzymes in ceramide metabolism. silymarin flavonolignans are potent apoptosis inducers and silibinin is the most active com...

The last two decades have witnessed explosive growth in the study of natural and other cancer chemopreventive agents (1, 2). Extensive preclinical data have been generated for natural agents, and many (such as green tea, curcumin, phenyl isothiocyanate, indole-3-carbinol, silibinin, lycopene, genistein, selenium, and vitamins A, E, and D) are currently in different phases of clinical testing (3...

INTRODUCTION Hepatitis C virus reinfection occurs universally after liver transplantation with accelerated cirrhosis rates of up to 30% within 5 years after liver transplantation. Management of hepatitis C virus reinfection is complicated by drug interactions and pre-treatment. Dual antiviral therapy with pegylated interferon and ribavirin only reaches sustained virological response rates of ap...

Background: Colorectal Cancer (CRC) is the most common malignant gastrointestinal cancer. stem cells (CSCs) are major cause of cancer recurrence and drug resistance. Silibinin, as an herbal compound, has anticancer properties. Objectives: The present study aimed to evaluate antiproliferative effects silibinin on HT29 stem-like (spheroids). Methods: In this study, apoptotic properties Silibinin ...

Bu çalışmada Ardıç bitkisi meyvelerinden deneysel tasarım yöntemiyle tasarlanan ekstraksiyon deneyleri gerçekleştirilmiş ve ekstraktlar içerisindeki Silibinin Rutin bileşiklerinin miktarları araştırılmıştır. geleneksel tıpta yüz yıllardır tedavi amaçlı olarak kullanıldığı için bilimsel çalışmalarda üzerinde araştırmaların yoğunlukla yapılan bir bitkidir. Geleneksel idrar söktürücü, iltihap önle...

BACKGROUND & AIMS Hepatitis C recurrence after liver transplantation (LT) is the main problem of most transplant programs. We aimed at assessing the antiviral activity and safety of intravenous silibinin (SIL) administered daily during the peri-transplant period. METHODS This was a single-centre, prospective, randomized, double-blind, placebo-controlled study including 14 HCV-infected patient...

DEAR EDITOR, We read with respect the paper “Protective role of Silymarin and deferoxamine against iron dextran induced renal iron deposition in male rats by Nematbakhsh et al. It is an interesting paper; however, I would like to add some complementary comments to it. In this paper the Silymarin reduced the kidney iron deposition in an iron overload model. The findings have demonstrated that Si...

Hypochlorous acid (HOCl) produced by myeloperoxidase (MPO) of activated neutrophils can react with nucleic acid bases to form chlorinated nucleosides such as 8-chloroguanosine (Cl-Guo). Chlorination is enhanced by nicotine. We investigated the effects of various natural antioxidants including polyphenolic phytochemicals on the formation of Cl-Guo by HOCl in the presence and the absence of nicot...