BACKGROUND Hypertension is the most prevalent and significant modifiable risk factor for coronary heart disease. A portion of patients with uncontrolled hypertension are considered to have resistant hypertension (RHTN). Myocardial ischemia incidence increases along with blood pressure (BP) levels. However, the prevalence of myocardial ischemia in patients with RHTN, as well as the factors assoc...

BACKGROUND AND PURPOSE Silent ischemic events are known to occur during diagnostic and interventional endovascular procedures between 10% and 69% of the time. The occurrence of silent and symptomatic ischemic events in the surgically treated population is not known, although atherosclerotic changes of intracranial vessels or within the aneurysms wall or neck area are seen often during surgery. ...

The prevalence of diabetes mellitus is fairly increasing, especially in the developing countries. Diabetes is a major cardiovascular risk factor; it often leads to severe cardiovascular complications, and coronary artery disease (CAD) is the main cause of death in diabetic patients. Silent myocardial ischemia (SMI) is more frequent in diabetic patients. The progress made in detection and treatm...

BACKGROUND Silent information regulator 1 (Sirt1), a class III histone deacetylase, retards aging and protects the heart from oxidative stress. We here examined whether Sirt1 is protective against myocardial ischemia/reperfusion (I/R). METHODS AND RESULTS Protein and mRNA expression of Sirt1 is significantly reduced by I/R. Cardiac-specific Sirt1(-/-) mice exhibited a significant increase (44...

The purpose of the following pilot study is to evaluate the possibility to detect the asymptomatic ischemic episodes which often precede dangerous events by means of endocardial signals. Intracardiac electrograms (IEGMs) have been detected in patients undergoing percutaneous transluminal coronary angioplasty (PTCA), a procedure during which ischemic episodes are induced. For 10 patients IECGs h...

Background. Type 2 diabetes mellitus (DM) is an important medical, social, and economic problem due to the high prevalence of disease, which often leads disability significantly increases mortality in elderly people. One causes coronary heart disease (CHD) patients with type DM autonomic cardiovascular neuropathy, characterized by damage nervous system manifests itself a varying clinical pictur...

BACKGROUND Critically ill adults admitted for noncardiac conditions are at risk for acute myocardial ischemia. OBJECTIVES To detect myocardial ischemia and injury in patients admitted for noncardiac conditions and to examine the relationship of myocardial ischemia, injury, and acuity to cardiac events. METHODS Transient myocardial ischemia, acuity, elevations in serum troponin I, and in-hos...