نتایج جستجو برای: sickle cell heart function tests
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In Cooley's anaemia the serum lipid fraction, determined by chemical analysis, was found to be decreased. The lipoprotein distribution by paper electrophoresis showed a characteristic pattern with abnormally low alpha(1) fraction and high concentrations of the beta fractions. There is no relationship between age and serum lipoprotein distribution. A correlation was found between the electrophor...
Ava II Site as a Marker of β-Globin Gene Polymorphism, among Normal and Sickle Cell Patients in Iran
The restriction enzyme Ava II detects the base change of the intervening sequence II (IVS II) which is used as one of the markers of β-globin gene polymorphism. This study was conducted to determine the frequency of the Ava II site on the β-globin gene among normal people and patients with sickle cell syndrome (SCS) in Iran. DNA fragments containing the IVS II region of the β-globin gene from...
This study sought to link cardiac phenotypes in homozygous Sickle Cell Disease (SCD) patients with clinical profiles and outcomes using cluster analysis. We analyzed data of 379 included the French Etendard Cohort. A analyses was performed based on echocardiographic variables, association between clusters, assessed. Three clusters were identified. Cluster 1 (n = 123) had lowest output, mild lef...
A Ghanaian family is described in which a sickle-cell haemoglobin C man married to a sickle-cell thalassaemia woman produced 12 children (eight alive). Four children have sickle-cell anaemia, two sickle-cell haemoglobin C disease, one has sickle-cell thalassaemia, and one is asymptomatic haemoglobin C thalassaemia.It is emphasized that the contribution that adult sickle-cell disease patients ma...
Modeling the complexity of sickle cell disease pathophysiology and severity is difficult. Using data from 3380 patients accounting for all common genotypes of sickle cell disease, Bayesian network modeling of 25 clinical events and laboratory tests was used to estimate sickle cell disease severity, which was represented as a score predicting the risk of death within 5 years. The reliability of ...
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