Time-domain equalization is crucial in reducing channel state dimension in maximum likelihood sequence estimation, and inter-carrier and inter-symbol interference in multicarrier systems. A time-domain equalizer (TEQ) placed in cascade with the channel produces an effective impulse response that is shorter than the channel impulse response. This paper analyzes two TEQ design methods amenable to...

STUDY OBJECTIVES Validation of test-shortening procedures for the 2-min tidal breathing methacholine challenge method. DESIGN Retrospective chart review. SETTING Tertiary-care university clinical pulmonary function laboratory. PATIENTS One thousand subjects aged 10 to 85 years (mean +/- SD, 44.5 +/- 16.0 years), 44.5% male, referred for methacholine challenge. INTERVENTION Two-minute ti...

Previously it was shown that left ventricular (LV) myocardial contractility can be assessed from the instantaneous relation between velocity of fiber shortening and maximum LV wall tension (VcF at max T). Such analysis is complex, requiring frame-by-frame correlation of LV dimensions with pressure, and a simpler approach was sought. In 50 patients the mean velocity of circumferential fiber shor...

volume. Intermediate levels of SERCA function ( 50% of control) had only minor hemodynamic effects. Parallel experiments in field-stimulated isolated ventricular cardiomyocytes monitored intracellular Ca and cell shortening. On perfusion with thapsigargin, Ca transient amplitude and cell shortening fell to 70% of control followed by increased diastolic Ca concentration and diastolic cell shorte...

BACKGROUND Dyssynchrony of myocardial deformation is usually described in terms of variability only (e.g. standard deviations SD's). A description in terms of the spatio-temporal distribution pattern (vector-analysis) of dyssynchrony or by indices estimating its impact by expressing dyscoordination of shortening in relation to the global ventricular shortening may be preferential. Strain echoca...

BACKGROUND Telomere/telomerase system has been recently recognized as an attractive target for anticancer therapy. Telomerase inhibition results in tumor regression and increased sensitivity to various cytotoxic drugs. However, it has not been fully established yet whether the mediator of these effects is telomerase inhibition per se or telomere shortening resulting from inhibition of telomeras...

BACKGROUND Until now, many investigators have focused on describing right ventricular (RV) dysfunction in groups of patients with pulmonary arterial hypertension (PAH), but very few have addressed the deterioration of RV function over time. The aim of this study was to investigate time courses of RV geometric changes during the progression of RV failure. METHODS Forty-two patients with PAH we...