OBJECTIVES To assess the frequency of serogroups and serotypes, as well as the antimicrobial susceptibility pattern of Shigella species isolated from known cases of diarrhoea and dysentery from Karachi, Pakistan. METHODS A cross-sectional study was conducted between January 2002 and March 2003 at Aga Khan University on stool samples received from children with diarrhoea and dysentery from fou...

Antibiotic resistance trends were examined for Shigella species, nontyphoidal Salmonella species, enterotoxigenic Escherichia coli (ETEC), and Campylobacter species isolates from indigenous persons and travelers in Thailand for up to 15 years. Resistance to trimethoprim-sulfamethoxazole was found in >90% of Shigella and 40% of ETEC and nontyphoidal Salmonella isolates. Resistance to nalidixic a...

TECHNICAL PAPERS A New Steric Effect in Organic Chemistry: Herbert C. Brown ......... .................................. 385 The Detoxification by Acetylation of Soluble Antigens From Shigella dysenteriae (Shiga) and E. typhosa: Henry P. Treffers ............................ ............... 387 On the Blocking Antibody and the Zone Phenomenon in Human Anti-Rh Sera: Philip Levine a dB.K. Waller ...

Shigella strains are in reality clones of Escherichia coli and are believed to have emerged relatively recently (G. M. Pupo, R. Lan, and P. R. Reeves, Proc. Natl. Acad. Sci. USA 97:10567-10572, 2000). There are 33 O-antigen forms in these Shigella clones, of which 12 are identical to O antigens of other E. coli strains. We sequenced O-antigen gene clusters from Shigella boydii serotypes 4, 5, 6...

A. Agent Hemolytic uremic syndrome (HUS) is a syndrome of anemia, renal failure and low platelet count, for which there are several causes. Among children, the most common cause of HUS is infection with a Shiga toxin-producing organism, most commonly Escherichia coli O157:H7 or some other strain of enterohemorrhagic E. coli (EHEC). Shigella dysenteriae also produces Shiga toxin and HUS can also...