OBJECTIVES To study the impact of obesity, age and varicocele on sexual hormones of adult and elderly men. MATERIALS AND METHODS 875 men who were screened for prostate cancer were enrolled in this study. Data recorded comprised age, body mass index (BMI), serum levels of total testosterone (TT), free testosterone (FT), sex hormone-binding globulin (SHBG), luteinizing hormone (LH) and follicul...

diabetes mellitus is a common metabolic disease. its association with low level of testosterone is controversial. this study aimed to investigate the association between serum total testosterone, free testosterone index (fti), and sex hormone-binding globulin (shbg) in iranian men with type 2 diabetic.a case-control study was conducted on 38 non-diabetic and 36 diabetic men aged 40-60 years old...

CONTEXT AND OBJECTIVE Metabolic syndrome consists of a set of factors that imply increased risk of cardiovascular diseases. The objective here was to evaluate the association between sex hormone-binding globulin (SHBG), sex hormones and metabolic syndrome among men. DESIGN AND SETTING Retrospective analysis on data from the study "Endogenous oestradiol but not testosterone is related to coron...

BACKGROUND Recent prospective studies have shown a strong inverse association between sex hormone-binding globulin (SHBG) concentrations and risk of clinical diabetes in white individuals. However, it remains unclear whether this relationship extends to other racial/ethnic populations. METHODS We evaluated the association between baseline concentrations of SHBG and clinical diabetes risk in t...

BACKGROUND Despite diffuse effects of sex hormones on the cardiovascular system, few prospective studies have examined the relationship of plasma androgens and estrogens with risk of cardiovascular disease (CVD) in postmenopausal women. METHODS AND RESULTS A nested case-control study was performed among women in the Women's Health Study. Two hundred women who developed CVD were matched 1:1 by...

Mathematical methods exist to determine the fractions of sex hormones bound to albumin, bound to sex hormone binding globulin (SHBG), or unbound, using total hormone concentration and SHBG concentration. We used data from eight prospective studies of postmenopausal women to assess the validity of these estimates for fractions of estradiol (E2) and to investigate the impact of using calculated v...

This systematic review aimed to assess variations in the clinical presentation and treatment outcomes of patients with polycystic ovary syndrome (PCOS) belonging different ethnicities. A search was performed for studies comparing various aspects PCOS two or more ethnic groups. After screening 2264 studies, 35 articles were included final analysis. In comparison White women (wPCOS), East Asian (...

Abstract Objectives Hyperandrogenism, a key feature of polycystic ovarian syndrome (PCOS), is caused by excess androgen secretion, most commonly origin. Although the serum total testosterone (TT) levels have long been used as traditional measure hyperandrogenemia in women with PCOS, it associated many fallacies due to fact that component TT linked sex hormone-binding globulin (SHBG). Recent res...