Glucose is essential for energy production in the living body; the glucose transporter plays a critical role in various organs. Glucose transporters are classified into two families: facilitative glucose transporters (GLUTs) and sodium-dependent glucose transporters (SGLTs), through which glucose is transported by facilitated diffusion, and Na/glucose are co-transported by an electrochemical gr...

SGLT2（sodium glucose cotransporter 2）阻害薬は糖尿病に対する血糖降下薬として開発されたが，心血管病リスクを有する2型糖尿病患者に対する心不全入院抑制作用が明らかとなった．それに引き続き，SGLT2阻害薬は，心機能低下を伴う慢性心不全患者の予後改善効果が明らかとなり，さらに最近，収縮力の保持された慢性心不全患者の予後改善効果も示された．現在各国の心不全ガイドラインにおいて心機能低下を伴う心不全患者に対しその使用が推奨されている．

Abstract Type 2 diabetes mellitus (T2DM) is a cardio-renal-metabolic condition that frequently associated with multiple comorbidities, including atherosclerotic cardiovascular disease (ASCVD), heart failure (HF), and chronic kidney (CKD). The sodium-glucose co-transporter-2 (SGLT2) inhibitors, which lower glycated hemoglobin, fasting postprandial plasma glucose levels, body weight, blood pressu...