OBJECTIVE To investigate whether maternal serum levels of adiponectin in the first trimester are altered in pregnancies that subsequently deliver small for gestational age (SGA) neonates. METHODS Maternal serum adiponectin and pregnancy-associated plasma protein A (PAPP-A) were measured at 11-13 weeks' gestation in 50 singleton normotensive pregnancies that delivered SGA neonates and 300 non-...

background: vitamin d deficiency during pregnancy is associated with some adverse pregnancy outcomes but its relationship with fetal growth is unknown. objective: we compared the 25-hydroxy vitamin d levels between mothers and their small for gestational age (sga) newborns with mothers and their appropriate for gestational age (aga) newborns. materials and methods: the study population included...

OBJECTIVE To review personal and published observations of giant cell (temporal) arteritis (GCA) or polymyal-gia rheumatica (PMR) with familial or conjugal aggregation and emphasise on epidemiological, clinical and genetic features of such cases. METHODS We pooled data obtained from all cases of GCA or PMR with familial aggregation recruited in the department since 1976 and those from reports...

INTRODUCTION Giant cell arteritis (GCA) is an autoimmune disease commonest in Northern Europe and Scandinavia. Previous studies report various associations with HLA-DRB1*04 and HLA-DRB1*01; HLA-DRB1 alleles show a gradient in population prevalence within Europe. Our aims were (1) to determine which amino acid residues within HLA-DRB1 best explained HLA-DRB1 allele susceptibility and protective ...

Sirs, Giant cell arteritis (GCA) is the most common systemic vasculitis in individuals over the age of 50 years in Western countries (1, 2). GCA is a polygenic disease and different genes may influence the phenotype and the outcome of this condition (3). Inflammatory cytokines, such as interferongamma (IFN-γ), play a role in the pathogenesis of GCA (4). A CA repeat polymorphism in the first int...

OBJECTIVE To evaluate the risk of cerebrovascular disease and cardiovascular disease (CVD) in patients with giant cell arteritis (GCA), and to identify predictors. METHODS The UK Clinical Practice Research Datalink 1991-2010 was used for a parallel cohort study of 5827 patients with GCA and 37,090 age-, sex-, and location-matched controls. A multivariable competing risk model (non-cerebrovasc...

Tan et al recently described a case of ''resistant giant cell arteritis'' successfully treated with etanercept. 1 Their patient, who had classical symptoms of polymyalgia rheu-matica (PMR), developed headaches while receiving low dose steroids. Biopsy of a temporal artery showed no arteritis. Because giant cell arteritis (GCA) was suspected on clinical grounds, high dose steroids were institute...

We show how data parallel operations can be implemented on a Global Cellular Automaton (GCA). For this purpose we implement a number of frequently used functions of the language APL. APL has been chosen because of the ability to express matrix and vector operations in a short and concise manner. It is shown how various operations on vectors and matrices can be executed through the execution of ...

Death due to giant cell arteritis (GCA) is rare, and is usually caused by coronary or vertebral arteritis in the acute phase of the disease. A case of fatal GCA is reported in a woman with a normal erythrocyte sedimentation rate, who had been treated for temporal arteritis for eight months. Post mortem examination showed a dissection and thrombosis of the intracranial portion of the left verteb...

OBJECTIVES It remains unclear why substantial variations in neurodevelopmental outcomes exist within small-for-gestational-age (SGA) children. We prospectively compared 5-y neurodevelopmental outcomes across SGA etiological subgroups. METHODS Children born SGA (N = 1050) from U.S. Early Childhood Longitudinal Study-Birth Cohort (2001-2007) was divided into etiological subgroups by each of 7 w...