BACKGROUND Tofacitinib is an oral Janus kinase inhibitor being investigated for psoriasis. A Phase 3 withdrawal/re-treatment study (NCT01186744; OPT Retreatment) showed tofacitinib re-treatment was effective in patients with chronic plaque psoriasis. OBJECTIVES To describe the effects of tofacitinib withdrawal/re-treatment on health-related quality of life (HRQoL) and disease symptoms measure...

Psoriasis is a chronic immune-mediated disorder that has a substantial impact on quality of life (1). It is characterized by systemic inflammation and cytokine dysregulation. In particular, alterations in T helper (Th) 1, Th17, and Th22 cells drive this disease with elevated serum concentrations of multiple proinflammatory cytokines, including TNF, IL-6, and IL-8 (1). Thus, monoclonal antibodie...

BACKGROUND AND OBJECTIVES the aim of this study was to design and assess the validity, reliability, and sensitivity to change of the Spanish Satisfaction With Treatment of Psoriasis Questionnaire (SSTPQ) for use in patients with moderate-to-severe psoriasis. PATIENTS AND METHODS a prospective, multicenter, observational, naturalistic study was designed. The instrument consisted of 12 items sc...

The role of vitamin D in psoriasis remains contradictory despite the fact that analogues constitute an established treatment for psoriasis. It has been proposed ability to exert anti-inflammatory effects might not depend solely on concentration serum 25(OH)D but also D-binding protein (DBP). High concentrations DBP diminish D’s biologic action. aims this study were (i) analyze levels DBP, total...

INTRODUCTION Platelet activation is elevated in moderate to severe psoriasis, and the reduction in platelet activation during short-term treatment has already been demonstrated. Soluble P-selectin is a well-established marker of platelet activation. AIM To show whether the long-term treatment of psoriasis with biological drugs can reduce elevated platelet activation. MATERIAL AND METHODS An...

Background: Psoriasis is a common chronic and recurrent inflammatory skin disease associated with increased risk of cardiovascular disease and cardiovascular risk factors such as obesity, diabetes mellitus, hypertension and hyperhomocysteinemia. Psoriasis also associated with increased risk of atherothrombosis. Objective: Evaluation of serum levels of inflammation and thrombophilia markers in p...

OBJECTIVE To explore the therapeutic effect of auricular therapy combined with optimized Yinxieling Formula on psoriasis vulgaris. METHODS A randomized controlled single-blind clinical trial on 84 outpatients with psoriasis vulgaris was conducted. The patients were randomized to a treatment group (43 cases treated by auricular therapy combined with optimized Yinxieling Formula) and a control ...

INTRODUCTION Psoriasis is a T cell-mediated inflammatory disease in which pathogenesis T helper (Th) lymphocytes (Th1, Th17, and Th22) play an important role. The aim of the study was to assess the serum levels of some cytokines involved in the Th17 and Th22 responses in psoriatic patients. MATERIAL AND METHODS The study comprised 60 psoriatic patients and 30 healthy controls. In the serum co...

This article describes the development, application, and validation of a scoring index for assessment of clinical signs in cats with flea allergy dermatitis (FAD). The Scoring Index for Clinical Signs of FAD was based on the evaluation and scoring of five signs over five anatomic areas, which is similar to the psoriasis area and severity index (PASI), a commonly used scoring method in human der...

BACKGROUND: Nailfold capillaroscopy is a useful technique for evaluating changes in microcirculation. OBJECTIVE: To investigate changes at nailfold capillaroscopy in psoriatic patients compared with controls. METHODS: Nailfold capillaroscopy was performed in 46 psoriatic patients and 50 controls to assess microscopic morphological changes, capillary density and the presence of areas with devasc...