In the South West Pacific region, the striking geographical correlation between the frequency of alpha+-thalassemia and the endemicity of Plasmodium falciparum suggests that this hemoglobinopathy provides a selective advantage against malaria. In Vanuatu, paradoxically, alpha+-thalassemia increases the incidence of contracting mild malaria in the first 2 years of life, but severe disease was to...

The first symptoms of malaria, common to all the different malaria species, are nonspecific and mimic a flu-like syndrome. Although fever represents the cardinal feature, clinical findings in malaria are extremely diverse and may range in severity from mil complications leading to death, particularly in falciparum malaria. As the progression to these complications can be rapid, any malaria pati...

APOBEC3B, a gene involved in innate response, exhibits insertion-deletion polymorphism across world populations. We observed the insertion allele to be nearly fixed in malaria endemic regions of sub-Saharan Africa as well as populations with high malaria incidence in the past. This prompted us to investigate the possible association of the polymorphism with falciparum malaria. We studied the di...

7. Jones KL, Donegan S, Lalloo DG. Artesunate versus quinine for treating severe malaria. Cochrane Database Syst Rev. 2007;(4):CD005967. 8. World Health Organization. Guidelines for the treatment of malaria. 2006 [cited 2008 Sep 11]. Available from http://www. who.int/malaria/docs/TreatmentGuidelines2006.pdf 9. Jelinek T. Intravenous artesunate recommended for patients with severe malaria: posi...

introduction: malaria is a protozoal disease, transmitted to humans by female anopheles mosquito bite. plasmodium falciparum, compared to other kinds of plasmodium, causes more severe malaria and is associated with a higher mortality rate. annually, one to three million deaths occur due to malaria, especially by p. falciparum. case presentation: in this report, we introduce an iranian patient s...

Malaria vivax is prevalent in many regions of the world. It is more prevalent in Asia and Latin America and accounts for more than half of all malaria cases in these two regions. Clinically severe cases and complications of malaria are commonly due to Plasmodium falciparum. Hematological changes are nearly common in malaria infection but severe thrombocytopenia is rare in P. vivax (1, 2). For m...

OBJECTIVE To compare the efficacy of artemether and quinine in the treatment of severe malaria in hospitalized children. STUDY DESIGN Open randomized trial. SETTING Pediatric ward of a tertiary care center. METHODS All children admitted with clinical manifestations of severe malaria (as per WHO criteria) and asexual forms of Plasmodium falciparum demonstrated on peripheral smear were rand...

Severe malarial anemia (MA) is the primary manifestation of severe malaria among children in areas of holoendemic Plasmodium falciparum transmission. Although overproduction of inflammatory-derived cytokines are implicated in the immunopathogenesis of severe MA, chemokines such as regulated on activation, normal T-cell expressed and secreted (RANTES, CCL5) are largely unexplored in childhood ma...

OBJECTIVE To study some hematological parameters in adult patients with complicated severe malaria and their relations to clinical outcome. MATERIALS AND METHODS This was a prospective study, including 77 patients from Aden Governorate with complicated severe malaria over the course of 2 years (2010-2011). RESULTS The common form of severe malaria in Aden was cerebral malaria (25.9%), follo...

Polymorphisms of ATP2B4 encoding an ubiquitous Ca(2+) pump protect against severe childhood malaria. We assessed the influence of a main polymorphism (rs10900585) on malaria among 834 delivering Ghanaian women. In homozygous primiparae, the odds of placental Plasmodium falciparum infection were reduced by 64%. No influence of the polymorphism on parasite density, low birth weight, or preterm de...