نتایج جستجو برای: sesquiterpene
تعداد نتایج: 2455 فیلتر نتایج به سال:
A short synthesis of the biologically active sesquiterpene natural product (+)-aphanamol I in both racemic and enantiopure forms is reported. Key steps include: a catalytic enantioselective conjugate addition, an oxidative radical cyclization, and a ring-expanding Claisen rearrangement.
The aerial parts of Inula verbascifolia afforded two new guaianolide-type sesquiterpene lactones. Their structures were determined by spectroscopic methods (IR, MS, 1H NMR, 13C NMR, DEPT, 1H-1H COSY, HMQC, and HMBC).
The structures of a new eudesmane sesquiterpene, lauradiol, and a new secoeudesmane, azoridione, have been determined by spectroscopic methods. These compounds and the known sesquiterpenic alcohols, clovanediol and caryophyllenol II, have been isolated from the aerial parts of Laurus azorica.
To overcome the potential future demand for terpenoids used as drugs, a new production platform is currently being established in our laboratory. The moss Physcomitrella has been chosen as the candidate organism for production of drug candidates based on terpenoids derived from plants, with a primary focus on the sesquiterpene lactone, thapsigargin. This drug candidate and other candidates/drug...
A new lactarane sesquiterpene, 1,2-dehydrolactarolide A (1), together with lactarorufin A (2), 3-O-ethyllactarolide A (3) and 3-O-ethyllactarolide B (4), was isolated from a mushroom of the Russulaceae family, Lactarius vellereus. Additionally, two lactarane sesquiterpenes, lactarorufin A (2) and lactarolide A (5) were isolated from L. subpiperatus. 1,2-Dehydrolactarolide A (1) showed promotion...
A.L. Cabrera's treatment of Argentine Vernonias (Cabrera, 1944) included four members of his Section Lepidaploa, subsection Flexuosae, three of which were listed as occurring in Entre Rios Province (Cabrera, 1974). Two of these, V. cognata Less. and V. platensis (Spreng.) Less., were said to be closely related, di!ering from each other only in the number of #owers in the capitulum, diameter of ...
BACKGROUND Sesquiterpenes are a class of natural products with a diverse range of attractive industrial proprieties. Due to economic difficulties of sesquiterpene production via extraction from plants or chemical synthesis there is interest in developing alternative and cost efficient bioprocesses. The hydrocarbon α-santalene is a precursor of sesquiterpenes with relevant commercial application...
Four sesquiterpene lactones, mikanolide, deoxymikanolide, dihydromikanolide and scandenolide, were isolated by a bioassay-guided fractionation of Mikania variifolia and Mikania micrantha dichloromethane extracts. Mikanolide and deoxymikanolide were the major compounds in both extracts (2.2% and 0.4% for Mikania variifolia and 21.0% and 6.4% for Mikania micrantha respectively, calculated on extr...
trans,trans-Farnesyl diphosphate (FPP) serves as a universal substrate for a large family of sesquiterpene cyclases that are responsible for biosynthesis of more than 300 structurally diverse sesquiterpenes in nature. A new FPP substrate analogue, 12-fluoro-farnesylphosphonophosphate (12-FF-CH2PP), was synthesized in this paper for applications on kinetic and mechanistic studies of the enzyme f...
The regulation of an elicitor-inducible sesquiterpene cyclase in tobacco (Nicotiana tabacum) cell suspension cultures was investigated. Sesquiterpene cyclase activity was absent from control cell cultures but induced to a maximum within 15 hours of cellulase addition to the cell cultures. The induction of the cyclase activity was correlated with an absolute amount of the cyclase protein as meas...
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