Micropatterning technologies are emerging as an enabling tool for various microfluidic-based applications in life sciences. However, the high throughput and multiplex localization of multiple bio-components in a microfluidic device has not yet been well established. In this paper, we describe a simple and in situ micropatterning method using an integrated microfluidic device with pneumatic micr...

We describe Zika virus (ZIKV) vertical transmission in an imported case in Spain, in a 17-week pregnant woman. ZIKV IgG, IgM and RNA were detected in serum in week 17. At 19 weeks, ultrasound scan revealed fetal malformations and ZIKV was detected in the amniotic fluid. Pregnancy was terminated at week 21; autopsy of the fetus revealed bilateral hydrocephalus, brain microcalcifications and arth...

Background: Abnormal umbilical cord pH can be indicated a distress imposed of newborn and can also be useful in determining the prognosis of the newborn. There are different views about the effect of the neonatal delivery method on the blood gas analysis of the umbilical artery. This study aimed to determine the effect of the method of delivery on umbilical artery pH. Methods: In this Cross ...

OBJECTIVE To investigate the effects of interventions promoting placental transfusion at delivery (delayed cord clamping or umbilical cord milking) compared with early cord clamping on outcomes among premature neonates of less than 32 weeks of gestation. DATA SOURCES A systematic search was conducted of PubMed, Embase, and ClinicalTrials.gov databases (January 1965 to December 2013) for artic...

Regulation of endothelial cell (EC) plasminogen activator inhibitor type-1 (PAI-1), the primary physiological inhibitor of tissue-type plasminogen activator (TPA) and urokinase-type plasminogen activator (UPA), by various stimuli has been well characterized. We report the upregulation of secreted and intracellular PAI-1 in human umbilical ECs when cocultured with human smooth muscle cells (SMCs...

Case report An eight year old boy presented with polyuria and polydipsia for 1 month. On examination, liver was not palpable but spleen was enlarged (6cm). Blood sugar was 460 mg/dl and type1 DM was confirmed. Ultrasonography showed portal vein cavernoma with normal liver and pancreas. Endoscopy revealed grade 2 esophageal varices. Thus diagnosis of EHPVO with portal hypertension was also confi...

The levels of four pregnanolone isomers and their polar conjugates and pregnenolone sulfate were measured in the plasma of 13 and 7 women at delivery with subarachnoidal and epidural analgesia, respectively, and in corresponding samples of umbilical plasma using a simple quadrupole GC/MS system with electron impact ionization (pregnenolone isomers), RIA following HPLC separation (pregnenolone) ...

objectives: considering the rarity of umbilical cord prolapse (ucp) and lack of accurate data about the risk factors and health outcomes, we aimed to evaluate cases of cesarean section (cs) due to ucp in order to reduce treatment costs and provide information about the mortality and morbidity associated with this condition.patients & methods: of 35,259 cases of cs performed in four hospitals du...

Procalcitonin (PCT) and C reactive protein (CRP) concentrations in umbilical cord blood of 197 neonates were measured to evaluate their value as markers of infection. Sixteen of the neonates were infected. The sensitivity, specificity, and negative and positive predictive values were respectively 87.5%, 98.7%, 87.5%, and 98.7% for PCT and 50%, 97%, 67%, and 94% for CRP. Serum PCT in cord blood ...