نتایج جستجو برای: serum leptin

تعداد نتایج: 319768  

Journal: :Clinical chemistry 2000
M Landt

BACKGROUND Leptin, a hormone produced primarily by adipose tissue, is known to be present in serum as both monomeric (free) and higher molecular mass (bound) forms, but little is known about the nature of the bound forms or physiological variation in binding capacity. METHODS A new method to quantify the free and bound forms was developed, based on HPLC separation and RIA quantification in ch...

Journal: :Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 2010
Anila Jalil Shahila Amir Rehan Majeed Farhan Jalil

Serum concentrations of leptin was investigated in 40 patients with ischemic stroke, in context of the size of the lesion and also in 40 non-diseased controls, matched according to age, gender and waist hip ratio. Serum leptin concentrations were determined in ng/ml with ELISA and computer tomography (CT) scan was performed in patients to estimate lesion size in cms. Serum leptin concentrations...

Journal: :The Journal of clinical endocrinology and metabolism 1997
M S Zumbach M W Boehme P Wahl W Stremmel R Ziegler P P Nawroth

Leptin is a pleiotropic hormone believed to regulate body weight. Its function in wasting during inflammatory disease in humans is unknown. We studied the effect of repeated tumor necrosis factor (TNF) infusion on serum leptin levels in six patients with solid tumors. TNF infusion on day 1 resulted in an increase in serum leptin levels from 3.1 (SEM +/- 0.28) ng/mL to 5.2 (SEM +/- 0.6) ng/mL af...

2015
Anna Baran Iwona Flisiak Jerzy Jaroszewicz Magdalena Świderska

INTRODUCTION Psoriasis is an inflammatory and chronic skin disease associated with obesity, cardiovascular diseases, diabetes and metabolic syndrome. Adipokines, as bioactive substances secreted from adipose tissue, are involved in various metabolic diseases. AIM To investigate the association between psoriasis severity and serum adiponectin and leptin levels in patients with psoriasis. MAT...

Journal: :Physiological research 2006
K Anderlová J Kremen R Dolezalová J Housová D Haluzíková M Kunesová M Haluzík

The aim of our study was to determine whether adipocyte-derived hormones leptin, adiponectin and resistin contribute to the improvement of insulin sensitivity after very-low calorie diet (VLCD). Therefore, serum levels of these hormones were measured in fourteen obese females before and after three weeks VLCD and in seventeen age- and sex-matched healthy controls. Body mass index, HOMA index, s...

2012
F.D. Zepf I. Sungurtekin F. Glass L. Elstrodt D. Peetz G. Hintereder J. Kratzsch C.S. Biskup F. Poustka L. Wöckel

BACKGROUND Evidence from animal studies suggests that leptin metabolism is associated with zinc (Zn) status. However, research investigating this relationship in adolescents and young adults with anorexia nervosa (AN) is scarce; the present study aims to fill that gap. METHODS Serum concentrations of leptin, the soluble leptin receptor (sOB-R) and the free leptin index (FLI) were obtained in ...

Recently, extensive efforts have been made to understand the rate of energy expenditure and the weight gain associated with atypical antipsychotic treatment, including identification of markers of obesity risk. In recent years, leptin, an adipocyte hormone, has gained significant interest in psychiatric disorders. S100B has been considered as a surrogate marker for astrocyte-specific damage in ...

Journal: :The Journal of clinical endocrinology and metabolism 1997
T R Nagy B A Gower R M Shewchuk M I Goran

Leptin has been hypothesized to play an important role in energy balance by affecting both energy intake and energy expenditure. The purpose of our study was to determine the relationship between fasting serum leptin concentrations and measures of energy expenditure in prepubertal children. We measured total energy expenditure (TEE; by the doubly labeled water technique), resting energy expendi...

2014
Jacek Przemyslaw Grabowski Anna Markowska Janina Markowska

AIM OF THE STUDY The available data on serum leptin levels in ovarian cancer present contradictory results. The majority of authors report lower leptin levels in those patients in comparison to healthy individuals. However, there is no data regarding leptin concentrations during therapy in women with primary epithelial ovarian cancer. MATERIAL AND METHODS Blood samples were collected at the t...

Journal: :The American journal of physiology 1999
G L Carlson M Saeed R A Little M H Irving

Circulating leptin concentrations are raised in animal models of inflammation and sepsis. The purpose of this study was to determine the effect of sepsis on serum leptin concentration in humans and to examine the relationship between leptin and the metabolic consequences of sepsis. Resting energy expenditure, insulin sensitivity, and fasting serum leptin, plasma insulin, and cortisol concentrat...

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