In this paper we present a method for determining the iron saturation of ferritin as a possible independent predictor of iron stores. Serum ferritin was purified by immunochemical precipitation, and could be completely recovered from serum without any contamination from transferrin. The iron content of the precipitated ferritin was determined by flameless atomic absorption spectrophotometry (FA...

We report the case of a 54-year-old man who presented with symptoms of idiopathic hemochromatosis, an inherited disorder involving regulation of iron absorption. These symptoms usually do not appear until total body iron content reaches 15 g, about threefold normal. Therapy involves mobilization and removal of excess stored iron through weekly or twice-weekly phlebotomies of 500 mL, until the h...

background: iron deficiency anemia is one of the important problems during pregnancy.  iron deficiency has several adverse effects on pregnant women and their newborns.   objective: to determine the status of iron store in newborns born to mothers with iron deficiency anemia.   methods: in a cross-sectional study, 90 mothers were categorized into three groups according to their pre-delivery hem...

Our aim was to evaluate the cut-off value and efficiency of using reticulocyte hemoglobin content as a marker to diagnose iron deficiency anemia in Chinese adults. 140 adults who needed bone marrow aspiration for diagnosis at the hematology department of the Peking Union Medical College Hospital were enrolled according to the inclusive and exclusive criteria. Venous blood samples were collected...

An automated procedurehas been developedfordeterminingserum iron content and iron-binding capacity with a new iron-chelating ligand, a 5. pyridyl.benzodiazepin-2-one derivative. A simplified manifoldand flowsystem, together with improved reagent combinations, offer distinct advantages over existing automated procedures. The results obtained by auto. mated analysis for serum iron and iron-bindin...

BACKGROUND Genetic variants of human transferrin (TF) have been described, but little is known about their functional differences. We studied iron status according to TF phenotype in a healthy Zimbabwean population and in subjects at risk of African iron overload. METHODS The study population consisted of 483 nondrinkers, 31 drinking spouse pairs, and 5 family pedigrees (n = 88) with index ca...

BACKGROUND Blood donation has a marked influence on the body iron stores especially in female blood donors. Iron deficiency anaemia is an important limiting factor for the number of donations in female regular blood donors. AIM OF THE STUDY This study was conducted to evaluate the frequency of iron deficiency and relevant factors in frequent and first time female blood donors at Casablanca bl...

The aim of the present study was to analyze brain and body iron levels among patients with mild cognitive impairment (MCI), Alzheimer's disease (AD), and normal controls (NCs). A total of 90 participants (30 MCI, 30 AD, 30 NC) were enrolled. Brain iron content was quantified using susceptibility weighted imaging (SWI). Phase values were used to calculate bilateral iron content in the hippocampu...

OBJECTIVE Malabsorption is one of the causes of iron deficiency anemia in postmenopausal women. The main objective of this study was to access the frequency of malabsorption in iron deficient anemic postmenopausal women. METHODS A total of 123 postmenopausal women were enrolled in the study. Of these 123 women, 50 were included as 'control group' and 73 patients with comparable severity of an...

The reaction of protoporphyrin with iron to form heme is usually studied in intact or lysed cells in the presence of salts of ionic iron. Despite the fact that such iron is utilized for heme synthesis, the form of iron available to erythropoietic cells in the intact animal is that which is present in serum in the form of a highly stable iron-protein complex, transferrin. Results obtained by use...