A 44 yr-old female with severe pulmonary emphysema and reduced alpha-1-protease inhibitor (alpha1-PI) serum levels developed an acute anaphylactic reaction following the third intravenous infusion of human alpha1-PI which was administered to prevent the progression of pulmonary emphysema. Specific immunoglobulin E-antibodies against human alpha1-PI could be demonstrated in the patient's serum u...

To rapidly quantify total immunoglobulin E levels in human serum, we developed a novel quantum-dot-based immunochromatographic assay that employs digital recording of fluorescence. It can detect IgE levels of 5-1000 kU/L, with a coefficient of variation ranging from 2.0 to 9.5%. The assay can be processed in 10 min. The developed assay was tested on 95 serum samples. The correlation coefficient...

Raised serum levels of immunoglobulin E (IgE) have been found in a variety of helminth infestations including Ascaris lumbricoides (Johansson, Mellbin &Vahlquist, 1968), Toxocara spp. (Hogarth-Scott, Johansson & Bennich, 1969), Trichinella spiralis (Rosenberg, Polmar & Whalen, 1971), Schistosoma Japonicum, Wuchereria bancrofti and hookworm (Ito, Sawada & Sato, 1972). Biroum-Noerjasin (1973) rep...

Horses have an increased susceptibility to infection because of a decline in immune function with advancing age. Vitamin E has been found to play a key role in normal immune system function. The purpose of the study was to examine the effect of vitamin E supplementation on immune function and response to vaccination in older horses. Predominantly older horses (18.9 +/- 1.3 yr, range 7 to 26 yr;...

Monitoring free serum IgE in severe asthma patients treated with omalizumab. 2 Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma. 2 Effects of adding omalizumab, an anti-immunoglobulin E antibody, on airway wall thickening in asthma. 3 A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study. 4 Reduction of total Ig...

A solid-phase radioimmunoassay was developed to detect immunoglobulin (Ig)E antibodies that bound to human IgG. IgE-rheumatoid factor activity was found in the serum of 18 of 20 patients with seropositive rheumatoid arthritis, 1 of 4 patients with seronegative rheumatoid arthritis, 3 of 32 patients with seronegative rheumatoid arthritis, 3 of 32 patients with asthma, and in 1 patient with hypoc...

Kimura's disease (KD) is an uncommon, chronic inflammatory disease characterized by tumor-like lesions in the soft tissue and lymph nodes and increased peripheral blood eosinophil counts and serum immunoglobulin E (IgE). Prednisone is widely used to treat the disease. Here, we reported a 59-year-old KD patient failed to response to prednisone. Leflunomide combined with methylprednisolone (Medro...

OBJECTIVE To investigate the pattern of sensitisation to aero-allergens and food allergens among asthmatic children in Hong Kong, and to investigate any correlation between atopy and the severity of asthma. DESIGN Consecutive case series. SETTING Paediatric out-patient clinic of a university teaching hospital, Hong Kong. PARTICIPANTS Two hundred and four consecutive children with physicia...