background and aims. gingival hyperplasia, a relatively common side effect of antiepileptic and anticonvulsant drugs, occurs in 30‒50% of patients taking phenytoin and 25‒81% of those taking cyclosporine. gingival hyperplasia due to lack of balance between extracellular synthesis and degradation is associated with increased production of il-1b, il-6 and il-8 by gingival fibroblasts. tissue leve...

BACKGROUND/AIM Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system. Effector T helper cells, mainly Th1 and Th17, cytotoxic T-cells, B-cells, macrophages, microglia, and the cytokines they secrete, are implicated in the initiation and maintenance of a deregulated immune response to myelin antigens and the ensuing immune-mediated demyelination. In this...

OBJECTIVES Systemic lupus erythematosus (SLE) is a multi-factorial, autoimmune disease with a wide array of manifestations. The pro-inflammatory cytokine interleukin (IL)-17 has been implicated in the inflammatory response and tissue damage in SLE; however, its correlation with disease activity is still questionable. Meanwhile, efficient clearance of apoptotic cells is required for immune toler...

Lupus nephritis is one of the most serious manifestations and one of the strongest predictors of a poor outcome in systemic lupus erythematosus (SLE). Recent evidence implicated a potential role of interlukin-17 (IL-17) in the pathogenesis of lupus nephritis. However, the correlation between IL-17 expression level and the severity of lupus nephritis still remains incompletely understood. In thi...

Interleukin (IL)-22, together with IL-23 and IL-17, is up-regulated in psoriatic lesions has been suggested to be involved the pathogenesis of psoriasis. However, while IL-17 have established as valid therapeutic targets psoriasis, anti-IL-22 antibody failed show its efficacy clinical trial for psoriasis vulgaris. Since it reported that better effect was achieved anti-TNFα antibodies arthritis ...

IL-17 is a pro-inflammatory cytokine implicated in the pathogenesis of glomerulonephritis and IL-17 deficient mice are protected from nephrotoxic nephritis. However, a regulatory role for IL-17 has recently emerged. We describe a novel protective function for IL-17 in the kidney. Bone marrow chimeras were created using wild-type and IL-17 deficient mice and nephrotoxic nephritis was induced. IL...

Pediatric obstructive sleep apnea (OSA) is associated with chronic systemic inflammation and with cognitive impairments. This study aimed to investigate the status of proinflammatory cytokines, particularly interleukin 17 (IL-17) and interleukin 23 (IL-23) and cognition in pediatric OSA.Controls and OSA children participated in the study. Exclusion criteria were adenotonsillectomy, heart, neuro...