PURPOSE The vancomycin dosage regimen is regularly modified according to the patient's glomerular filtration rate (GFR). In the present study, we aimed to assess the usefulness of serum cystatin C (Cys-C) concentration, compared with serum creatinine (SCr) concentration, for predicting vancomycin clearance (CLvcm) in neonates. METHODS We retrospectively analyzed the laboratory data of 50 term...

BACKGROUND Identifying methods to accurately measure the glomerular filtration rate (GFR) in obese individuals without kidney overt kidney disease is necessary to understanding the pathophysiology and natural history of obesity-related kidney disease. METHODS Using a cross-sectional design, iohexol clearance and disposition was measured, an optimal sampling schedule was identified, and the re...

ABSTRACT Background Inter-individual variations of non-glomerular filtration rate (GFR) determinants serum creatinine, such as muscle mass, account for the imperfect performance estimated GFR (eGFR) equations. We aimed to develop an equation based on creatinine and total lumbar cross-sectional area measured by unenhanced computed tomography scan at third vertebra. Methods The mass–based eGFR (M...

BACKGROUND No conventional creatinine- or cystatin C-based glomerular filtration rate (GFR) estimation equation performed consistently outstandingly in elderly Chinese in our previous studies. This research aimed to further evaluate the performance of some recently proposed estimation equations based on creatinine and cystatin C, alone or combined, in this specific population. MATERIALS AND M...

Current estimates suggest that as many as one in six persons in North America have chronic kidney disease,1 a condition that may worsen over time and signal the need for continuous monitoring. Knowing which patient with chronic kidney disease is at risk for end-stage kidney disease or death could tell us who needs intensive monitoring or intervention. The glomerular filtration rate (GFR), the c...

INTRODUCTION Fluid resuscitation in the critically ill often results in a positive fluid balance, potentially diluting the serum creatinine concentration and delaying diagnosis of acute kidney injury (AKI). METHODS Dilution during AKI was quantified by combining creatinine and volume kinetics to account for fluid type, and rates of fluid infusion and urine output. The model was refined using ...

Introduction: In recent years diffusion weighted MRI (DWI) has begun to be applied outside of the central nervous system, with researchers examining DWI of the abdominal and pelvic organs. Initial studies of DWI in the kidneys [1-3] have shown a relationship between the apparent diffusion coefficient (ADC) in renal parenchyma and renal function, with scan subjects with elevated serum creatinine...

AIM The aim of this study was determination of validity of 99mTcDTPA estimation of GFR for early detection of chronic kidney failure. MATERIAL AND METHODS There were 110 patients (54 males and 56 females) with kidney disease referred for evaluation of renal function at UCC of Kosovo. All patients were included in two groups. In the first group were included 30 patients confirmed with renal fa...

We examined the correlation between the glomerular filtration rate (GFR) estimated from an equation based on the serum iodixanol clearance technique and International Renal Interest Society (IRIS) stages of chronic kidney disease (CKD) in cats. The equation included the injection dose, sampling time, serum concentration and estimated volume of distribution (Vd) of the isotonic, nonionic, contra...