hemiscorpius lepturus is medically important scorpion species present in the south and southwest part of iran, causing morbidity and mortality in children and adults. unlike other scorpions studied so far, the venom of h. lepturus is highly cytotoxic, that can be a reason for its complexity in clinical manifestations in patients stung by this scorpion. scarce studies showed the mechanism involv...

background and aims: some nanoparticles can be used in immunoassays to increase sensitivity. this study aimed to evaluate a novel nano-immunoassay based on bovine serum albumin nanoparticles (bsa nps). materials and methods: at first, the nanostructure was synthesized, and then applied as a tag in the nano-immunoassay. then the concentration of β-subunit of human chorionic gonadotropin (βhcg) i...

a quantitative analysis method for fudosteine in human serum by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry (hplc-esi/ms/ms) was established, which shows high sensitivity and selectivity. the mobile phase composition was 75% 20 mm acetic acid and 25% acetonitril, which was pumped at a flow rate of 0.40 ml/min. the overall chromatographic run time was ...

to study the changes of serum uric acid level which is influenced by various factors including nutrition, race, socio-economic conditions age, sex, obesity and hyper lipidemia, a wide variety of survey appeared to be performed. for this study in six large provinces of iran out of 12,524 apparently healthy individuals a total of 2,744 persons of both sexes (1,439 females, 1,305 males) were selec...

background: the aberrant expression of dickkopf-1 (dkk1), triose phosphate isomerase (tpi) and fatty acid binding-protein 5 (fabp5) in lung cancer tissues and their presence in secretome of lung cancer cell lines were reported. here, serum levels of these molecules in lung cancer patients were compared to those in a healthy control group. materials and methods: the patients’ group consisted of ...

allergic rhinitis (ar) is a very frequent disease which is not only characterized by nasal symptoms, but also with behavioural changes. this study evaluated the serum serotonin levels in patients with pollen-induced ar during and outside the pollen season. one-hundred-two  (56 females, 46 males, median age: 28.7 years) were included in this study: 56 with seasonal ar (sar) evaluated outside the...

introduction: controlling and reducing serum uric acid levels may have beneficial effects on blood pressure control. the current study was carried out to assess the effects of allopurinol administration on serum uric acid and arterial blood pressure among the patients under hemodialysis.  methods: this double-blind clinical trial was conducted on 132 hemodialysis patients (two separate groups) ...

background: the immunogenic brucella abortus ribosomal protein l7/l12 is a promising candidate antigen for the development of subunit vaccines against brucellosis. objective: this study was aimed to evaluate the protection of recombinant human serum albumin (has)-l7/l12 fusion protein in balb/c mice. methods: the amplified l7/l12 gene was cloned in pyhsa5 vector, pyhsa5-l7/l12 construct was tra...

a simple, rapid, selective and highly sensitive fluorimetric method for determination of two catecholamines, i.e. norepinephrine (ne) and epinephrine (ep), in serum samples was developed. the method is based on the fluorescence sensitization of terbium (tb3+) by complexation with both catecholamines in the presence of lanthanum (la3+), as a co-cation, and in a na2so3 solution (chemical deoxygen...

in india, the occurrence of diabetes mellitus is on increase and needs to be addressed properly. herbal remedies are considered most suitable for the management of type 2 diabetes due to their traditional acceptability and availability, low costs, and fewer side effects. traditionally bauhinia tomentosa l. (family- fabaceae) is used in the treatment of diabetes in india. aqueous extract and alc...