This study presents a pharmacokinetic-pharmacodynamic based clinical trial simulation framework for evaluating the performance of a fixed-sample Bayesian design (BD) and two alternative Bayesian sequential designs (BSDs) (i.e., a non-hierarchical (NON-H) and a semi-hierarchical (SEMI-H) one). Prior information was elicited from adult trials and weighted based on the expected similarity of respo...

Decision makers are often unable to choose between the options that they are offered. In these settings they typically defer their decision, that is, delay the decision to a later point in time or avoid the decision altogether. In this paper, we outline eight behavioral findings regarding the causes and consequences of choice deferral that cognitive theories of decision making should be able to...

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Resonance assignment is the first stage towards solving the structure of a protein. This is normally achieved by the employment of separate inter and intra residue experiments. By utilising the mixed rotation and rotary recoupling (MIRROR) condition it is possible to double the information content through the efficient bidirectional transfer of magnetization from the CO to its adjacent Cα and t...

Mechanisms Underlying Broad Spectrum Resistance Genome-wide interactions between Xanthomonas oryzae pv. oryzae (Xoo) and rice resulting from a broad-spectrum hypersensitive reaction (BSHR) mediated by a new rice R gene, Xa39, were investigated by comparative dynamic transcriptomic profiles in the incompatible and compatible interactions using three related rice lines and a highly virulent Xoo i...

Coherent dual comb spectroscopy can provide high-resolution, high-accuracy measurements of a sample response in both magnitude and phase. We discuss the achievable signal-to-noise ratio (SNR) due to both additive white noise and multiplicative noise, and the corresponding sensitivity limit for trace gas detection. We show that sequential acquisition of the overall spectrum through a tunable fil...

Hereditary spastic paraplegias are a clinically and genetically heterogeneous group of disorders characterized by lower extremity spasticity and weakness. Recently, the first de novo mutations in KIF1A were identified in patients with an early-onset severe form of complicated hereditary spastic paraplegia. We report two additional patients with novel de novo mutations in KIF1A, hereby expanding...

In this paper we evaluate two statistical approaches to semi-automated texture enhancement and discrimination for landslide mapping in semi-arid, sedimentary terrain from Daedalus ATM data. A supervised texture discrimination technique is applied, based on calculating similarity between a reference texture spectrum obtained from training samples and spectra from moving image windows. The result...

We investigate power allocation for users in a spectrum underlay cognitive network. Our objective is to find a power control scheme that allocates transmit power for both primary and secondary users so that the overall network throughput is maximized while maintaining the quality of service (QoS) of the primary users greater than a certain minimum limit. Since an optimum solution to our problem...

We present a method for calculating the full current noise spectrum S(ω) for the class of nano-electromechanical systems (NEMS) that can be described by a Markovian generalized master equation. As a specific example we apply the method to a quantum shuttle. The noise spectrum of the shuttle has peaks at integer multiples of the mechanical frequency, which is slightly renormalized. The renormali...