Whilst it is common in clinical trials to use the results of tests at one phase to decide whether to continue to the next phase and to subsequently design the next phase, we show that this can lead to biased results in evidence synthesis. Two new kinds of bias associated with accumulating evidence, termed 'sequential decision bias' and 'sequential design bias', are identified. Both kinds of bia...

The sequential design method is presented as a complementary tool of the systematical synthesis procedure that allows to define a clear connection among the different types of distillation column sequences. In particular, the connection with the simple column subspace is considered, since this subspace represents the comparison reference for all the alternatives considered. The sequential desig...

The embedding of test patterns into a sequential circuit is the main topic of this paper. Deterministic test patterns for the sequential circuit under test are chosen to be embedded into hybrid cellular automata (CA). Test identification and C.A synthesis are performed in parallel thus overcoming results achieved by embedding pre-computed vectors. The theory of sequential test generation under ...

Sequential pattern mining is advantageous for several applications for example, it finds out the sequential purchasing behavior of majority customers from a large number of customer transactions. However, the existing researches in the field of discovering sequential patterns are based on the concept of frequency and presume that the customer purchasing behavior sequences do not fluctuate with ...

The sequential synthesis problem, which is closely related to Church’s solvability problem, asks, given a specification in the form of a binary relation between input and output streams, for the construction of a finite-state stream transducer that converts inputs to appropriate outputs. For efficiency reasons, practical sequential hardware is often designed to operate without prior initializat...

Microwave-enhanced, highly efficient protocols for the synthesis of synthetically and biologically important 2,3,6-trisubstituted pyridazine architectures have been developed by sequential amination/Suzuki coupling/alkylation reactions. This powerful strategy is an economical and highly chemoselective protocol for the synthesis of diversified pyridazines. The total synthesis of gabazine (SR-955...