dna methylation is an important biological process involving in human disease such as cancer insomia and diabetes. bisulfite sequencing (bs-seq) with next-generation technology is an accurate method for measuring dna methylation. bs-seq data analysis is a considerable way to recognize methylated cytosines and several tools have been developed to analysis bs-seq such as bs-seeker, b-solana, brat...

background: acanthamoeba spp. is the causative agent of blindness keratitis and fatal encephalaitis. presence of acanthamoeba spp. in a wide variety of niches such as different water types can lead to exposure of high risk people such as contact lens wearers. the main aim of the present study was to explore the occurrence of acanthamoeba genotypes in the recreational water sources using both mo...

objective: toxoplasmosis, caused by an intracellular protozoan parasite, and the toxoplasma gondii, is widespread throughout the world. in recent years, significant progress has been made in the identification of vaccine candidates which could induce a protective response. gra7, an excretory 29 kda toxoplasma gondii a dense granular antigen released by infected host cells. in tachyzoite-infect...

In this paper, an integrated machine scheduling withits due date setting problem has been considered. It is assumed that the machine is subject to some kind of random unavailability. Due dates should be set in an attractive and reliable manner, implying that they should be short and possible to be met. To this end, first, long due dates are penalized in the objective function. Then, for each cu...

In automated float glass manufacturing, a continuous ribbon of glass is cut according to customer orders and then offloaded using robots. We consider the problem of laying out and sequencing the orders on the ribbon so as to minimize waste. The problem combines characteristics of cutting, packing, and sequencing problems. Given the size and the complexity of the problem, we propose a two-phase ...

The paper deals with a stochastic multi-product sequencing and lot-sizing problem for a line that produces items in lots. Two types of uncertainties are considered: random lead time induced by machine breakdowns and random yield to take into account part rejects. In addition, sequence dependent setup times are also included. This study focuses on maximizing the probability of producing a requir...

The paper deals with a stochastic multi-product sequencing and lot-sizing problem for a line that produces items in lots. Two types of uncertainties are considered: random lead time induced by machine breakdowns and random yield to take into account part rejects. In addition, sequence dependent setup times are also included. This study focuses on maximizing the probability of producing a requir...