No form of organization has ever existed without leadership. However, an individual need not be the senior officer or commander to be a leader. Nevertheless, for an organization to function with some degree of efficiency, having a leader at its head is important. If a leader is also a good manager, that is even better. While leadership and management are terms that are often used interchangeabl...

Background. Single-cell RNA-Seq is a new technique that can measure gene expression levels in individual cells. We would like to use single-cell RNA-seq data to learn genetic regulatory networks. This is a natural task for causal-model structurelearning algorithms, which aim to learn the causal relationships between the measured variables. Causal algorithms perform poorly in high dimensions unl...

Assay for Transposase Accessible Chromatin (ATAC-seq) is an open chromatin profiling assay that is adapted to interrogate chromatin accessibility from small cell numbers. ATAC-seq surmounted a major technical barrier and enabled epigenome profiling of clinical samples. With this advancement in technology, we are now accumulating ATAC-seq samples from clinical samples at an unprecedented rate. T...

Microarray expression analyses following miRNA transfection/inhibition and, more recently, Argonaute cross-linked immunoprecipitation (CLIP)-seq assays have been used to detect miRNA target sites. CLIP and expression approaches measure differing stages of miRNA functioning-initial binding of the miRNP complex and subsequent message repression. We use nonparametric predictive models to character...

RNA sequencing (RNA-Seq) is a powerful method for discovering, annotating, and quantifying RNA transcripts that is currently revolutionizing the field of agrigenomics.1–9 RNA-Seq does not require speciesor transcript-specific probes, enabling precise quantification of both known and novel transcripts without prior knowledge. Beyond the measurement of gene expression changes, RNA-Seq can be used...

conclusions our results show the presence of clonal groups of enterotoxin-producing mrsa strains in this hospital in tehran. the presence of bacteriophage encoded virulence factors and resistance to oxacillin enable bacteria to produce a broad spectrum range of diseases. results out of the 279 s. aureus isolates, 91 (32.6%) strains were confirmed as mrsa. totally, 6 enterotoxin and 2 virulence ...