dismiss the possibility of hypertext support for computational applications, when in fact hypertext functionality can supplement an application’s computational power. In this article we describe how developers can incorporate hypertext functionality into computational applications. What benefit do users gain from hypertext support in computational applications? Managing the myriad of interrelat...

Compensation plays an important role in advanced transaction models, cooperative work, and workflow systems. However, in spite of the fact that the correctness of a system may depend on compensation operations, little attention has been devoted to the specification of these operations and the verification of their ability to compensate. In fact, compensation operations are often simply written ...

It was previously assumed that the X-linked recessive mutation, sepia, induced errors in X-chromosome elimination during early embryogenesis of Sciara ocellaris. The results obtained in the present analysis corroborate this assumption and permit a further classification of the type of error this mutation induces. Among 85,244 individuals analyzed, three kinds of aberrant flies were identified: ...

The faces ofBlack and White men and women stare back from the sepia-colored pages of the past. These images, set between the pages of a tattered black photograph album, are a record ofa bygone era. Men and women, Blacks and Whites, all gathered together to record their experiences of the summer of 1915: the setting, rural Alabama, the participants, Negro teachers, White supervisors, and a speci...

It is shown that ultrafiltration could be the first step in urine formation in Sepia officinalis and Octopus vulgaris. The organization of the podocytes indicates that ultrafiltration can occur through these cells. They have a thick basal lamina in contact with the peripheral blood lacunae, and the cell apices lie in infoldings of the lumen of the appendage. Comparison between the colloid-osmot...

The immune system of cephalopods remains poorly understood. The aim of this study was to determine the specific activity of immune enzymes in epithelial barriers, circulatory and digestive systems of the common cuttlefish Sepia officinalis. Three enzyme groups with putative functions in immunity were investigated: phenoloxidases (POs), lysozymes and protease inhibitors (PIs). Consistent with a ...

OBJECTIVE There is great controversy concerning treatment for menopausal symptoms. We evaluated homeopathic treatments for hot flushes and their effect on quality of life in menopausal women. METHODS Open, multi-national prospective, pragmatic and non-comparative observational study of homeopathic treatments prescribed and their effectiveness, observing their impact on quality of life. RESU...

Acetylcholine (ACh), which is synthesized from choline (Ch), is believed to hold a central place in signaling mechanisms within the central nervous system (CNS) of cuttlefish (Sepia officinalis) and other coleoid cephalopods. Although the main elements required for cholinergic function have been identified in cephalopods, the transmembrane translocation events promoting the release of ACh and t...

OBJECTIVES With the development of sophisticated instruments for the isolation and elucidation of natural products structures from marine and freshwater organisms, major advances have been made in the discovery of aquatic derived therapeutics. Present investigations were carried out to evaluate cuttlefish (Sepia officinalis) ink extract (IE) and freshwater clam (Coelatura aegyptiaca) extract (C...