3,4,5-trimethoxycinnamic acid (TMCA) is one of the constituents in Onji (roots of Polygala tenuifolia WILLD), an herbal medicine used for sedative in Japanese traditional Kampo medicine. Our previous study revealed that oral administration of this compound prolongs sleeping time induced by hexobarbital in mice to exhibit sedative action. In the present study, we investigate the effects of TMCA ...

Anxiety is a most common emotional disorder affecting 20% of adult population worldwide. Eclipta alba is having memory enhancing quality & traditionally used for this purpose. Since paucity of data available for this clinical use, the present work was undertaken to study the anti anxiety & sedative effects of Ethanolic extract of leaves of Eclipta alba(EEEA) in albino rats using thiopental sodi...

The sedative effects of pentazocine 50 mg given orally have been studied in 100 healthy gynaecological patients using a standard scoring system. It was found that pentazocine produced mild sedation which was not significantly greater than that produced by a placebo in the numbers studied. The incidence of complications was low and while there was a higher incidence of postoperative nausea and v...

OBJECTIVES To quantify and compare potential benefits (subjective reports of sleep variables) and risks (adverse events and morning-after psychomotor impairment) of short term treatment with sedative hypnotics in older people with insomnia. DATA SOURCES Medline, Embase, the Cochrane clinical trials database, PubMed, and PsychLit, 1966 to 2003; bibliographies of published reviews and meta-anal...

Background: Preoperative anxiety and parental deprivation remains a challenge to anesthesiologists.Dexmedetomidine (DexM) has sedative analgesic effects via central action. Ketamine (KET) is an N-methyl-d-aspartate (NMDA) receptor antagonist that produces state of sedation. Nebulization harmless, rapid absorption, inexpensive administration route. The aim this work was compare the effectiveness...

An acute allergic reaction in a 5-year-old healthy male, after receiving midazolam by intranasal atomizer for sedation purposes in the dental clinic, was reported. Shortly after the midazolam was provided, the child developed urticaria in both ankles, which rapidly progressed to the lower extremities, stomach, back, arms, neck, and face. The periorbital skin also became edematous. In the emerge...

Metabolically critical illness can be divided in two phases, acute and prolonged. Whereas the acute or hypermetabolic phase is characterized by elevated circulating concentration of catabolic hormones and substrate utilization to provide energy to vital organs, the prolonged or catabolic phase of critical illness is marked by reduced endocrine stimulation and severe loss of body cell mass. The ...

Elderly patients presenting cardiovascular, respiratory, or neurological disorders require a specific dental care approach, especially patients presenting Alzheimer's disease. Sedative procedures can prevent dental care-induced stress, even when there is effective pain control, but they have to be adapted to accommodate age-induced physiological modifications, age-related pathologies, and the c...