Syringomyelia is a progressive neurological disorder in which fluid-filled cyst known as syrinx forms within the spinal cord. The case of 20-year adult presented with lower limb stiffness and difficulty walking for last 3 years. For 1 year, he also developed upper limbs. Upon examination, had spastic gait no ataxia. There was muscle wasting both limbs, fasciculation. Tone increased reduced powe...

Recent advances in defining neurotrophin signaling mediators have provided insights into the signal transduction mechanisms that underlie axon growth. Evidence is accumulating that major Trk effectors regulate the morphological development of embryonic peripheral neurons. Less is known about signaling related to the robust axon extension that follows peripheral axotomy of adult neurons. Regener...

In sensory neurons of the peripheral nervous system, receptor potentials can be amplified by depolarizing Cl currents. In mammalian olfactory sensory neurons (OSNs), this anion-based signal amplification results from the sequential activation of two distinct types of transduction channels: cAMP-gated Ca channels and Ca-activated Cl channels. The Cl current increases the initial receptor current...

Nociception, the sensory mechanism that allows animals to sense and avoid potentially tissue-damaging stimuli, is critical for survival. This process relies on nociceptors, which are specialized neurons that detect and respond to potentially damaging forms of energy - heat, mechanical and chemical - in the environment. Nociceptors accomplish this task through the expression of molecules that fu...

There are two opposing hypotheses about the brain mechanisms underlying sensory event-related potentials (ERPs). One holds that sensory ERPs are generated by phase resetting of ongoing electroencephalographic (EEG) activity, and the other that they result fiom signal averaging of stimulus-evoked neural responses. We tested several contrasting predictions of these hypotheses by direct intracorti...

Neural Recording Systems Inkjet-printed organic voltage amplifiers, which integrate electrochemical transistors with thin-film resistors on flexible substrates, as reported by George G. Malliaras, Sungjune Jung, and co-workers in article number 2301782, are found to enhance vivo brain monitoring. The design optimizes signal processing at sensor endpoints, minimizing noise increasing the efficie...

Why are sensory modalities segregated the way they are? In this paper we show that sensory modalities are well designed for self-supervised crossmodal learning. Using an unsupervised speech categorization task with visual (moving lips) and auditory (sound signal) inputs, we show that very informative auditory dimensions actually harm performance when moved to the visual side of the network. It ...

Visuospatial experience, the prolonged engagement in a demanding visual task, obtained through action video game play enhances several visual and cognitive processes. The underlying mechanisms involved in these processes, however, remain unclear. Here we demonstrate that experience with action video games modulates early sensory processing, resulting in increases sensitivity to salient visual e...

Atomic resolution structures of a sensory rhodopsin phototaxis receptor in haloarchaea (the first sensory member of the widespread microbial rhodopsin family) have yielded insights into the interaction face with its membrane-embedded transducer and into the mechanism of spectral tuning. Spectral differences between sensory rhodopsin and the light-driven proton pump bacteriorhodopsin depend larg...

Sexual signals are often complex and perceived by multiple senses. How animals integrate signal components across sensory modalities can influence signal evolution. Here we show that two relatively unattractive signals that are perceived acoustically and visually can be combined in a pattern to form a signal that is attractive to female túngara frogs. Such unanticipated perceptual effects sugge...