KEY FINDINGS Sensory impairments are a substantial problem for older Americans: One out of six has impaired vision; one out of four has impaired hearing; one out of four has loss of feeling in the feet; and three out of four have abnormal postural balance testing. Sensory impairments increase with age: Vision and hearing impairments each double, and loss of feeling in the feet increases by 40% ...

We disrupted periodicity cues by temporally jittering the speech signal to explore how such distortion might affect word identification. Jittering distorts the fine structure of the speech signal with negligible alteration of either its long-term spectral or amplitude envelope characteristics. In Experiment 1, word identification in noise was significantly reduced in young, normal-hearing adult...

Background: Mutations in DNA methyltransferase 1(DNMI1)have been identified in 2 autosomal dominant syndromes: 1-) hereditary sensory autonomic neuropathy with dementia and hearing loss (HSANlE); and 2) cerebellar ataxia, deafness, and narcolepsy. Both syndromes have mutations in targeting sequence (TS) domain (exons 20-21), which is important in mediating DNA substrate binding to the DNMT1 cat...

The number of persons with hearing and vision loss is on the rise as lifespans increase. Vision plays an important role in communication, especially in the presence of background noise or for persons with hearing loss. However, persons with vision loss cannot make use of this extra modality to overcome their hearing deficits. We propose automatically utilizing some visual information in hearing...

Matrix metalloproteinases (MMPs) and their related gene products regulate essential cellular functions. An imbalance in MMPs has been implicated in various neurological disorders, including traumatic injuries. Here, we report a role for MMPs and their related gene products in the modulation of cochlear responses to acoustic trauma in rats. The normal cochlea was shown to be enriched in MMP enzy...

Introduction Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) can involve multiple systems and cause stroke-like episodes and status epilepticus. Case Presentation A 48-year-old female with history of early fatigability, migraine-type headaches, and bilateral sensory-neural hearing loss presented 3 episodes of serial seizures. On admission she was affected by We...

Abstract Date Presented 04/22/2023 Children born with sensorineural hearing loss (SNHL) are at a higher risk for motor, sensory, and social development delays. This study reveals gap between what is assessed treated the challenges experienced by children SNHL. Primary Author Speaker: Sophie Sherman

Sensory training therapies for tinnitus are based on the assumption that, notwithstanding neural changes related to tinnitus, auditory training can alter the response properties of neurons in auditory pathways. To assess this assumption, we investigated whether brain changes induced by sensory training in tinnitus sufferers and measured by electroencephalography (EEG) are similar to those induc...

There is clear evidence for cross-modal cortical reorganization in the auditory system of post-lingually deafened cochlear implant (CI) users. A recent report suggests that moderate sensori-neural hearing loss is already sufficient to initiate corresponding cortical changes. To what extend these changes are deprivation-induced or related to sensory recovery is still debated. Moreover, the influ...

Subjective tinnitus is commonly experienced, especially by those with hearing loss. It is generally agreed that neural plasticity underlies the pathophysiology of subjective tinnitus. Studies from audiology/hearing research and cognitive neuroscience/neuropsychology are reviewed to illuminate current understanding of the pathophysiology of tinnitus. Research has revealed hyperactivity (increase...