Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to induce apoptosis in prostate cancer cells through DR4 and DR5 death receptors, but not in normal prostate cells, which do not express these receptors. Therefore, TRAIL has excellent potential to be a selective prostate cancer therapeutic agent with minimal toxic side effects. However, prostate cancer cells, as man...

Effect of Different Levels Sodium Selenate and Selenite on Morphological Characteristics Nutrients Concentration in Peppermint

Several aquatic species were examined as potential phytoremoval agents for selenium in aqueous solutions. Selenium was initially present in concentrations of 0-100 ppm Se (as sodium selenite) in 10% Hoagland’s medium, and aquatic plants were grown in the medium for one week. Four aquatic plants were studied: Cattail ( Typha domingensis ), duckweed ( Lemna obscura ), hydrilla ( Hydrilla verticil...

OBJECTIVE To evaluate the antioxidative and anticataractogenic potential effect of ursodeoxycholic acid (UDCA) on selenite-induced cataract in vitro and in vivo. METHODS Enucleated rat lenses were incubated in M199 medium alone (Group I), with 200 μM selenite (Group II), or with 200 μM selenite and 500 μM UDCA (Group III). Selenite was administered on the third day and UDCA treatment was from...

Sodium selenite is a trace element essential for many physiological functions in the body. It is involved in various biological processes; it acts as a cofactor for antioxidant enzymes that protect against free radicals and is reported to limit metal-mediated oxidative DNA damage. In the present study, we investigated the effect of sodium selenite on neomycin ototoxicity in wild-type and transg...

Shewanella sp. HN-41 was exploited for selenium nanoparticles synthesis from aqueous selenite compounds under anaerobic conditions. Various reaction conditions, including reaction time, initial biomass, and initial selenite concentration, were systematically investigated to determine their effects on particle size distribution and formation rate. The biomass concentration of Shewanella sp. HN-4...

Selenium (Se) is an essential element with a small difference between physiological and toxic doses. To provide more effective and safe Se dosing regimens, as compared to dosing with ionic selenium, nanoparticle formulations have been developed. However, due to the nano-formulation, unexpected toxic effects may occur. We used metabolite pattern determination in urine to investigate biological a...

It is well known that in general, an increased oxidative stress is found in cancer cells (e.g. [1, 2]). Low and high LET radiations induce reactive oxidative species and thus increase the oxidative stress even more. Different cancer cells not only do repair the DNA damage differently, they also cope differently with oxidative stress. Increasing the oxidative stress before irradiation might poss...

BACKGROUND Selenium and Tellurium have many common chemical properties as both belong to group 16 of the periodic table. High toxicities of Se and Te oxyanions cause environmental problems in contaminated soils and waters. Three strains (C4, C6 and C7) of selenite reducing and nanoparticle forming aerobic bacteria which were isolated from agricultural soils of India containing high concentratio...