A primer extension (toeprinting) assay was used to monitor selection by ribosomes of the first versus the second AUG codon as a function of introducing mutations on the 3' side (positions +4, +5 and +6) of the first AUG codon. Six different flanking codons starting with G (GCG, GCU, GCC, GCA, GAU and GGA) strongly augmented selection of AUG#1 when compared with matched mRNAs that had A or C ins...

Posture analysis in quiet standing is a key component of the clinical evaluation of Parkinson’s disease (PD), postural instability being one of PD’s major symptoms. The aim of this study was to assess the feasibility of using accelerometers to characterize the postural behavior of early mild PD subjects. Twenty PD and 20 control subjects, wearing an accelerometer on the lower back, were tested ...

Genome-wide association studies provide an unprecedented opportunity to identify combinations of genetic variants that contribute to disease susceptibility. The combinatorial problem of jointly analyzing the millions of genetic variations accessible by high-throughput genotyping technologies is a difficult challenge. One approach to reducing the search space of this variable selection problem i...

We examine in this paper the subset selection procedure in the context of ordinal optimization introduced in [1]. Major concepts including goal softening, selection subset, alignment probability and ordered performance curve are formally introduced. A two-parameter model is devised to calculate alignment probabilities for a wide range of cases using two di erent selection rules: Blind Pick and ...

Health Monitoring systems with textile sensors offer more comfort compared to gel electrodes, however they tend to suffer from poor skin contact and motion artifacts. In order to improve the monitoring reliability, we propose to apply multiple sensors and context aware sensing. A context aware monitoring system can adapt monitoring according to changes in the environment and the behavior of peo...

This paper presents a novel approach for mobile phone centric observation of a user’s facing direction, relying solely on built-in accelerometer and magnetometer. Our approach achieves greater accuracy and independence by an automatic detection of the wearing position of the mobile device on the user’s body and subsequent selection of an optimum strategy for estimating the user direction. We re...

purpose: to evaluate ophthalmologists’ sitting position during ocular examination and surgery and to evaluate any correlation between musculoskeletal disorders and mean work time.   methods: this cross-sectional study was performed on ophthalmologists in isfahan, iran in different occupational positions including the office, during slitlamp examination and in the operating room. the evaluation ...

The ParetoGP algorithm which adopts a multi-objective optimization approach to balancing expression complexity and accuracy has proven to have significant impact on symbolic regression of industrial data due to its improvement in speed and quality of model development as well as user model selection, [1], [2], [3]. In this chapter, we explore a range of topics related to exploiting the Pareto p...