We report a case of frontal lobe epilepsy due to focal cortical dysplasia that included three independent unusual features. The patient, a 45-year-old, right-handed woman, had her first seizure at age 29, well into adulthood. Seizures had been easily controlled with medication for 15 years, then without provocation they became medically intractable during a single, identifiable day. Resection o...

We report the results of a double-blind cross-over study comparing clobazam and placebo in the treatment of refractory childhood epilepsy. Fifty-two percent of patients had greater than 50% reduction in their seizure frequency when taking the clobazam. During the placebo phase no patient recorded a greater than 50% reduction in seizure frequency. Sex, age, seizure type, intellect did not appear...

This paper will attempt to identify some of the major methodological hurdles that are present when treating or researching seizure conditions using neurobehavioural approaches. An overview of the unique methodological problems that arise with behavioural/psychological treatments will be discussed. The author will focus on personal experiences with complex and simple partial seizures, looking in...

Seizures triggered by visual stimuli are the most common type of reflex seizure. Self-induced seizures produced by stimulation of natural light are rare and self-induction is a mode of seizure precipitation employed by either intellectually disabled or healthy photosensitive individuals. Absences and myoclonic jerks are the most common seizure types in self-induction. We report on a girl with n...

Nicotine, acting through the neuronal nicotinic acetylcholine receptors (nAChRs), can induce seizures in mice. We aimed to study brain transcriptional response to seizure and to identify genes whose expression is altered after nicotine-induced seizures. Whole brains of untreated mice were compared with brains 1 h after seizure activity, using Affymetrix U74Av2 microarrays. Experimental groups i...

OBJECTIVE We aimed to report the pattern of usage and efficacy of antiepileptic drugs (AEDs) in patients with autoimmune epilepsy (AE). METHODS We retrospectively studied the Mayo Clinic's electronic medical record of patients with AE in which seizures were the main presenting feature. Clinical data, including demographics, seizure characteristics, type of AED and immunotherapy used, presence...

PURPOSE To present the interim findings of the Epilepsy Birth Control Registry (EBCR) regarding the impact of various contraceptive methods on seizures, stratified by antiepileptic drug (AED) type. METHODS This is an observational study that reports interim findings on the first 750 subjects. RESULTS There are significantly greater relative risks (RR) for both seizure increase and decrease ...

BACKGROUND Seizure as the initial manifestation of aortic dissection is rare. CASE REPORT An 88-year-old female experienced a first generalized tonic clonic seizure, which was terminated with midazolam. Acute cerebral magnetic resonance imaging and angiography were non-informative. After awaking she complained about cramping pain in the right upper extremity, which was accompanied by involunt...

Persistent homology is a novel multi-scale topological method that is gaining popularity in data analysis. It has proven effective in revealing nonlinear patterns of high-dimensional imaging data that are otherwise undetected by existing mono-scale techniques. Among several descriptors of persistent homology, the recently proposed PL possess many desirable properties for rigorous statistical in...