Removing the germline of Caenorhabditis elegans extends lifespan. This lifespan extension requires the nuclear receptor DAF-12 and the cytochrome P450 DAF-9, suggesting that a lipophilic hormone is involved. Here we show that C. elegans contains several hormonal steroids that are also present in humans, including pregnenolone (3beta-hydroxy-pregn-5-en-20-one; PREG) and other pregnane and andros...

Numerical weather prediction is characterized by high-dimensional, nonlinear systems and poses difficult challenges for real-time data assimilation (updating) and forecasting. The goal of this work is to build on the ensemble Kalman filter (EnsKF) to produce ensemble filtering techniques applicable to non-Gaussian densities in high dimensions. Two filtering algorithms are presented which extend...

Many concepts require generalizing number. For example, concepts such as momentum and energy conservation apply to arbitrary numbers of physical objects, clearing the top of a desk can require an arbitrary number of object relocations, and setting a table involves an arbitrary number of guests. In addition. there is recent psychological evidence [Ahn87] that people can generalize number on the ...

A 73-year-old female developed right facial paralysis of House-Brackmann (H-B) grade III and was diagnosed with Bell's palsy. After three months steroid therapy, she progressive hearing loss, an MRI revealed a tumor in the internal auditory canal. Within few months, nerve palsy recurred, patient treated Gamma Knife radiosurgery. The irradiated region disappeared, but new dysphagia observed, par...

this paper describes the application of approximate methods to invert airborne magnetic data as well as helicopter-borne frequency domain electromagnetic data in order to retrieve a joint model of magnetic susceptibility and electrical resistivity. the study area located in semnan province of iran consists of an arc-shaped porphyry andesite covered by sedimentary units which may have potential ...