نتایج جستجو برای: secondary progressive multiple sclerosis

تعداد نتایج: 1161733  

Journal: :Brain : a journal of neurology 1996
J W Thorpe D Kidd I F Moseley A J Thompson D G MacManus D A Compston W I McDonald D H Miller

Although MRI detects the white matter lesions of multiple sclerosis within the brain with high sensitivity, a minority of patients have normal brain MRI. We describe 20 patients, selected from over 170 who had undergone brain imaging with minimal (n = 12) or no (n = 8) abnormalities (median number of lesions = I, range, 0-3) but in whom spinal MRI was abnormal. Twelve had clinically definite or...

Journal: :iranian journal of immunology 0
mahmood soveid endocrine and metabolism research center peyman petramfar department of neurology, shiraz university of medical sciences, shiraz, iran

high cortisol level in endogenous cushing’s syndrome suppresses the immune system and after treatment there may be an over activity of immune reaction leading to autoimmune diseases mostly thyroid and rheumatologic disorders. this is the second reported case of multiple sclerosis developing after treatment of cushing’s syndrome. a 42-year old man is reported who presented with bone fracture and...

1998
C A Davie G J Barker A J Thompson P S Tofts W I McDonald D H Miller

Objectives—To test the hypothesis that irrecoverable neurological deficit in multiple sclerosis is associated with axonal loss. Methods—H magnetic resonance spectroscopy (MRS) was carried out in a group of patients with clinically definite multiple sclerosis (n=31). Using this technique, the apparent concentration of NA ([NA] the sum of N-acetyl aspartate (NAA), a neuronal marker, and N-acetyla...

Journal: :Noro psikiyatri arsivi 2015
Aslı Köşkderelioğlu Muhteşem Gedizlioğlu Pınar Ortan Özge Öcek

INTRODUCTION In this article, we report the data regarding treatment adherence of a group of patients with multiple sclerosis (MS) and relapsing-remitting or secondary progressive disease who were followed in the MS outpatient clinic of Bozyaka Education and Research Hospital, Izmir. METHODS We collected the demographic data of 219 patients with MS who were treated with immunomodulatory drugs...

2016
Emanuele D’Amico Francesco Patti Aurora Zanghì Mario Zappia

Using the term of progressive multiple sclerosis (PMS), we considered a combined population of persons with secondary progressive MS (SPMS) and primary progressive MS (PPMS). These forms of MS cannot be challenged with efficacy by the licensed therapy. In the last years, several measures of risk estimation were developed for predicting clinical course in MS, but none is specific for the PMS for...

Journal: :Multiple sclerosis 2017
Michela Tinelli Panos Kanavos Olina Efthymiadou Erica Visintin Federico Grimaccia Jean Mossman

The International MultiPlE Sclerosis Study (IMPrESS) studied the significant impact of multiple sclerosis (MS) on the health and well-being of both people with the disease and their caregivers, along with its broader socioeconomic impact. Results confirmed that there is an urgent need to achieve better outcomes for people with MS. This paper uses results from the IMPrESS to present new internat...

Mahmood Soveid, Peyman Petramfar

High cortisol level in endogenous Cushing’s syndrome suppresses the immune system and after treatment there may be an over activity of immune reaction leading to autoimmune diseases mostly thyroid and rheumatologic disorders. This is the second reported case of multiple sclerosis developing after treatment of Cushing’s syndrome. A 42-year old man is reported who presented with bone fracture and...

2015
Claire M. Rice David I. Marks Yoav Ben-Shlomo Nikos Evangelou Paul S. Morgan Chris Metcalfe Peter Walsh Nick M. Kane Martin G. Guttridge Gail Miflin Stuart Blackmore Pamela Sarkar Juliana Redondo Denise Owen David A. Cottrell Alastair Wilkins Neil J. Scolding

BACKGROUND We have recently completed an evaluation of the safety and feasibility of intravenous delivery of autologous bone marrow in patients with progressive multiple sclerosis (MS). The possibility of repair was suggested by improvement in the neurophysiological secondary outcome measure seen in all participants. The current study will examine the efficacy of intravenous delivery of autolog...

Journal: :Brain : a journal of neurology 2015
Caterina Mainero Céline Louapre Sindhuja T Govindarajan Costanza Giannì A Scott Nielsen Julien Cohen-Adad Jacob Sloane Revere P Kinkel

We used a surface-based analysis of T2* relaxation rates at 7 T magnetic resonance imaging, which allows sampling quantitative T2* throughout the cortical width, to map in vivo the spatial distribution of intracortical pathology in multiple sclerosis. Ultra-high resolution quantitative T2* maps were obtained in 10 subjects with clinically isolated syndrome/early multiple sclerosis (≤ 3 years di...

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